Energy restriction does not prevent insulin resistance but does prevent liver steatosis in aging rats on a Western-style diet

Hennebelle, Marie; Roy, Maggie; St-Pierre, Valérie; Courchesne-Loyer, Alexandre; Fortier, Mélanie; Bouzier‐Sore, Anne‐Karine; Gallis, Jean‐Louis; Beauvieux, Marie-Christine; Cunnane, Stephen C.

doi:10.1016/j.nut.2014.09.009

Cited by 7 publications

(5 citation statements)

References 65 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TWD+ and TWD-resulted in significant increases in hepatic total fatty acids at postpartum only (73.1 ± 25.4 and 77.2 ± 33.3 mg/g) that suggested progression towards fatty liver. Total hepatic fatty acid concentrations of 122 mg/g and percentage shifts towards higher 18:1n-9 and lower 18:0 has been observed previously in rats with steatosis [49]. This was not present during pregnancy, and was not reflected in ACCEPTED MANUSCRIPT…”

Section: A C C E P T E D Msupporting

confidence: 60%

Concentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancy

Lamontagne-Kam

Chalil

Henao

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

Highlights DHA supplementation is examined in rats during pregnancy with a background diet that resembles human Western diets and a standard rodent chow.  DHA concentrations are lower in maternal adipose during pregnancy and postpartum in the Western diet without DHA.  At postpartum DHA concentrations decrease below baseline levels in maternal heart and liver of the dams fed Western diets without DHA and in liver in the chow diet.  Low maternal DHA intakes was associated with lower DHA concentrations in the 7d old pups but not the fetuses

show abstract

Section: A C C E P T E D Msupporting

confidence: 60%

Concentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancy

Lamontagne-Kam

Chalil

Henao

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

show abstract

“…IMF also increased insulin resistance at the fasting state. Hennebelle et al 44 showed that energy restriction does not prevent insulin resistance and elevated serum triglycerides. However, in the present study, IMF lowered serum triglyceride levels, although it did exacerbate insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats

Shin

Kang

Kim

et al. 2018

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Intermittent fasting may be an effective intervention to protect against age-related metabolic disturbances, although it is still controversial. Here, we investigated the effect of intermittent fasting on the deterioration of the metabolism and cognitive functions in rats with estrogen deficiency and its mechanism was also explored. Ovariectomized rats were infused with β-amyloid (25-35; Alzheimer's disease) or β-amyloid (35-25, Non-Alzheimer's disease; normal cognitive function) into the hippocampus. Each group was randomly divided into two sub-groups: one with intermittent fasting and the other fed ad libitum: Alzheimer's disease-ad libitum, Alzheimer's disease-intermittent fasting, Non-Alzheimer's disease-ad libitum, and Non-Alzheimer's disease-intermittent fasting. Rats in the intermittent fasting groups had a restriction of food consumption to a 3-h period every day. Each group included 10 rats and all rats fed a high-fat diet for four weeks. Interestingly, Alzheimer's disease increased tail skin temperature more than Non-Alzheimer's disease and intermittent fasting prevented the increase. Alzheimer's disease reduced bone mineral density in the spine and femur compared to the Non-Alzheimer's disease, whereas bone mineral density in the hip and leg was reduced by intermittent fasting. Fat mass only in the abdomen was decreased by intermittent fasting. Intermittent fasting decreased food intake without changing energy expenditure. Alzheimer's disease increased glucose oxidation, whereas intermittent fasting elevated fat oxidation as a fuel source. Alzheimer's disease and intermittent fasting deteriorated insulin resistance in the fasting state but intermittent fasting decreased serum glucose levels after oral glucose challenge by increasing insulin secretion. Alzheimer's disease deteriorated short and spatial memory function compared to the Non-Alzheimer's disease, whereas intermittent fasting prevented memory loss in comparison to ad libitum. Unexpectedly, cortisol levels were increased by Alzheimer's disease but decreased by intermittent fasting. Intermittent fasting improved dyslipidemia and liver damage index compared to ad libitum. Alzheimer's disease lowered low-density lipoprotein cholesterol and serum triglyceride levels compared to Non-Alzheimer's disease. In conclusion, Alzheimer's disease impaired not only cognitive function but also disturbed energy, glucose, lipid, and bone metabolism in ovariectomized rats. Intermittent fasting protected against the deterioration of these metabolic parameters, but it exacerbated bone mineral density loss and insulin resistance at fasting in Alzheimer's disease-induced estrogen-deficient rats. Impact statement Intermittent fasting was evaluated for its effects on cognitive function and metabolic disturbances in a rat model of menopause and Alzheimer's disease. Intermittent fasting decreased skin temperature and fat mass, and improved glucose tolerance with decreasing food intake. Intermittent fasting also prevented memory loss: short-term and special memory loss. ...

show abstract

“…Interestingly, increased levels of hippurate and dimethylgycine have been considered as age-induced biomarkers [64,65]. Their decreased levels in aged mammals resulting from a 40% restricted dietary CR treatment for 12 weeks may be the effect of modulated gut microbiota activity and improved nutrient digestibility, thereby providing supporting evidence for the beneficial effect of CR as anti-aging and causing increased longevity [66].…”

Section: Host-microbial Co-metabolitesmentioning

confidence: 99%

“…In db/db mice, reduction in the levels of most glycerolipids [diacylglycerol (DG) and TG] and related hepatic enzymes were observed [4]. In NAFLD, the CR-induced reduction of liver triglyceride (TG) may have contributed to the prevention of further hepatic alterations associated with insulin resistance (IR) [66]. Notably, the decreased level of SM (d18:0/16:1) was observed in overweight and obese women after eight weeks of CR intervention [74], whereas the proportion of plasma SM increased with age and was elevated in obese models [75,76].…”

Section: Lipidsmentioning

confidence: 99%

Calorie restriction and its impact on gut microbial composition and global metabolism

Zheng

Wang

2018

Front. Med.

View full text Add to dashboard Cite

Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.

show abstract

Energy restriction does not prevent insulin resistance but does prevent liver steatosis in aging rats on a Western-style diet

Cited by 7 publications

References 65 publications

Concentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancy

Concentrations of docosahexaenoic acid are reduced in maternal liver, adipose, and heart in rats fed high-fat diets without docosahexaenoic acid throughout pregnancy

Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats

Calorie restriction and its impact on gut microbial composition and global metabolism

Contact Info

Product

Resources

About