Energy restriction restores the impaired immune response in overweight (cafeteria) rats

Lamas, Oscar; Martínez, J. Alfredo; Marti, Amelia

doi:10.1016/j.jnutbio.2004.02.003

Cited by 74 publications

(53 citation statements)

References 48 publications

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“…Energy restriction results in significant reduction of leptin levels and altered ObR b mRNA expression in rat splenocytes (43). Exogenous leptin replacement modulates T cell responses in mice and prevents starvation-induced immunosuppression (13) and alters thymic cellularity and lymphoid atrophy (37).…”

Section: Leptin and States Of Immune Dysfunction: Energy Deficiency Amentioning

confidence: 99%

“…Leptin levels are increased and mRNA expression of the ObR b receptor isoform may be decreased in diet-induced obese vs control rats, indicating a state of leptin resistance (43). In rodent models of diet-induced obesity, thymic lymphopenia, lower mitogenic response of splenocytes, and suppressed NK cytotoxic activity have been observed (47).…”

Section: Leptin and States Of Immune Dysfunction: Energy Deficiency Amentioning

confidence: 99%

“…Similarly, in obese subjects, T lymphocyte subpopulations (CD3 ϩ , CD4 ϩ CD45RO ϩ , CD8 ϩ ) and their proliferative response to polyclonal mitogens are also suppressed (48). These immune abnormalities are reversed with energy restriction (which decreases leptin levels) in both humans and animals (43). Although the exact mechanism for these immune defects in obesity remains largely unknown, leptin levels are correlated not only with the organism's energy status but also with serum TNF-␣ levels which are also elevated in obesity and have a suppressive effect on lymphocyte function (48,49).…”

Section: Leptin and States Of Immune Dysfunction: Energy Deficiency Amentioning

confidence: 99%

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Leptin in Immunology

Matarese

Moschos

Mantzoros

2005

The Journal of Immunology

516

426

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Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.

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Section: Leptin and States Of Immune Dysfunction: Energy Deficiency Amentioning

confidence: 99%

Section: Leptin and States Of Immune Dysfunction: Energy Deficiency Amentioning

confidence: 99%

Section: Leptin and States Of Immune Dysfunction: Energy Deficiency Amentioning

confidence: 99%

See 1 more Smart Citation

Leptin in Immunology

Matarese

Moschos

Mantzoros

2005

The Journal of Immunology

516

426

View full text Add to dashboard Cite

show abstract

“…Alimentos Ltda) with tap water provided ad libitum. The SO and EO groups, from the second month of life, followed a hyperlipidic diet (cafeteria diet), as used by Panveloski-Costa et al (2011), adapted from Lamas et al (2004).…”

Section: Methodsmentioning

confidence: 99%

Can the Intermittent Training Generate Alterations on the Liver Tissue of Rats Submitted to a Hyperlipidic Diet?

et al. 2016

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SUMMARY Studies indicate that increasing physical activity and decreasing levels of fat in the liver help to decrease the risk of morbidity from liver conditions. This study aimed to evaluate the effects of an eight week intermittent training program on the liver tissue of rats subjected to a hyperlipidic diet. The study consisted of 30 male Wistar rats, divided into the following groups: Sedentary Control (SC) Exercise Control (EC) (fed on standard feed and water) Sedentary Obese (SO) and Exercise Obese (EO) (fed on bacon, ham, sausage, biscuits, soda and standard feed), which performed intermittent training through electrically stimulated jumps, with three sets of 12 repetitions, three times per week for eight weeks. At the end of the training period, the animals were euthanized, and their livers removed for histological processing and hematoxylin and eosin staining (HE). Soon afterwards, caryometric analysis of the hepatocyte nuclei was performed. From the presented results it can be seen that the hepatocyte nuclei of the obese animals were smaller in relation to those of the control animals, therefore, exercise combined with an appropriate diet proved to be efficient in not causing alterations in the hepatocyte nuclei, conserving normal cell function and reducing the chances of the appearance of tissue damage. Furthermore, exercise in isolation cannot be considered a protective factor against the alteration of the liver cells.

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“…It is also impaired in db/db mice and fa/fa rats whose mutation in leptin receptor gene [15,16]. Suppression of immune responses are also observed in diet-induced obese mice [17][18][19] or rats [20,21]. Both cellular and humoral immunity are dampened in overweight Mongolian gerbils (Meriones unguiculatus) [22].…”

Section: Introductionmentioning

confidence: 99%

High Body Mass Has No Effect on Cellular and Innate Immunity in Siberian Hamsters (<i>Phodopus sungorus</i>)

Tian¹,

Chen²,

Cui³

et al. 2017

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Body mass is considered to be related with immune function in animals. Our aim was to test the hypothesis that cellular and innate immunity would be suppressed in high body mass of Siberian hamsters (Phodopus sungorus). Six heavier (high body mass, HBM) and six lighter (low body mass, LBM) hamsters were selected from 28 male hamsters. Body mass, body fat mass, wet spleen mass and blood glucose levels were significantly higher in the HBM group than in the LBM group. However, phytohaemagglutinin response, serum bacteria killing capacity and white blood cells did not differ between the two groups, suggesting cellular and innate immunity was not impaired in high body mass of hamsters. There was no correlation between cellular, innate immunity and body mass, body fat mass and glucose levels, suggesting cellular and innate immunity was not suppressed by higher body mass, body fat mass and glucose levels. In summary, cellular and innate immunity was not impaired in the HBM hamsters compared with the LBM hamsters.

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Energy restriction restores the impaired immune response in overweight (cafeteria) rats

Cited by 74 publications

References 48 publications

Leptin in Immunology

Leptin in Immunology

Can the Intermittent Training Generate Alterations on the Liver Tissue of Rats Submitted to a Hyperlipidic Diet?

High Body Mass Has No Effect on Cellular and Innate Immunity in Siberian Hamsters (<i>Phodopus sungorus</i>)

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Energy restriction restores the impaired immune response in overweight (cafeteria) rats

Cited by 74 publications

References 48 publications

Leptin in Immunology

Leptin in Immunology

Can the Intermittent Training Generate Alterations on the Liver Tissue of Rats Submitted to a Hyperlipidic Diet?

High Body Mass Has No Effect on Cellular and Innate Immunity in Siberian Hamsters (&lt;i&gt;Phodopus sungorus&lt;/i&gt;)

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Resources

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High Body Mass Has No Effect on Cellular and Innate Immunity in Siberian Hamsters (<i>Phodopus sungorus</i>)