Energy supply to nuclear transport in cardiomyocytes

Dzeja, Petras P.; Bortolon, Ryan; Perez‐Terzic, Carmen; Holmuhamedov, Ekshon L.; Terzic, André

doi:10.1016/s0022-2828(01)90120-8

Journal of Molecular and Cellular Cardiology

2001

DOI: 10.1016/s0022-2828(01)90120-8

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Energy supply to nuclear transport in cardiomyocytes

Petras P. Dzeja¹,

Ryan Bortolon²,

Carmen Perez‐Terzic³

et al.

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“…CK inhibition diminishes the velocity of phosphoryl transference, reducing instantaneous creatine pool in cytosol and mitochondria, causing an alteration in the energy homeostasis (Nasrallah et al 2010). Both enzymes, CK and AK, are intimately associated in such a way that when one enzyme activity is reduced, the activity of the other enzyme is enhanced (Dzeja et al 2002). Diminution of cytosolic CK and AK activities reduces energy homeostasis, partially compensated through glycolytic phosphoryl transfer (Janssen et al 2003).…”

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Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney

Rech

Mezzomo

Athaydes

et al. 2017

An. Acad. Bras. Ciênc.

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Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16 th to the 20 th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/ disulfide ratio and co-administration with cystine dimethyl ester prevented the inhibition of the enzymes. Regression between the thiol/disulfide ratio, and the kinases activities were significant. These results suggest that redox status may regulate energy metabolism in the rat kidney. If thiol-containing enzymes inhibition and oxidative stress occur in patients with cystinosis, it is possible that lysosomal cystine depletion may not be the only beneficial effect of cysteamine administration, but also its antioxidant and thiol-protector effect.

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mentioning

confidence: 99%

Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney

Rech

Mezzomo

Athaydes

et al. 2017

An. Acad. Bras. Ciênc.

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Energy supply to nuclear transport in cardiomyocytes

Cited by 1 publication

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Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney

Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney

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