Enfermedad de Crohn: ¿todavía hoy causa de fiebre de origen desconocido clásica?

Muñoz, Miriam Estébanez; Hernandez, Francisco; Cerezo, Jorge Gómez; Rodríguez, M. López; Muñoz, B. Pagán; Rodríguez, J J Vázquez

doi:10.4321/s0212-71992007000400007

Cited by 3 publications

(2 citation statements)

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“…Familial mediterranean fever and Crohn’s disease usually present with FUO. Muñoz et al,5 report two patients with Crohn’s disease who presented with fever of unknown origin, and mild intestinal symptoms. Kikuchi-Fujimoto disease is described as a recent cause of FUO, it is a histocytic necrotizing lymphadenitis that presented with lymphadenopathy and prolonged fever, elevated erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, rarely bilateral pleural effusion, and interstitial lung disease, SLE and other causes of FUO are the differential diagnosis 6,7…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin

Abdelbaky

Mansour

Ibrahim

et al. 2011

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Objective:To estimate the prevalence of connective tissue diseases in patients presenting with fever of unknown origin (FUO).Patients and methods:In this study thirty patients diagnosed as FUO (Group 1), in 2008, were included in an observational study and diagnostic workup. Additionally, retrospective analysis of seventy patients’ files (Group 2), for patients who presented with prolonged unexplained pyrexia to the same hospital in the previous two years, was performed. Patients were subjected to: full clinical assessment including full history taking, thorough clinical examination, laboratory investigations including the basic investigations for patients with prolonged fever, complete blood count, erythrocytes sedimentation rate, urine analysis and culture, blood culture, sputum culture and plain chest X ray. Further diagnostic work up and/or procedures were requested according to the potential diagnostic clues (PDC) present in every patient.Results:Out of 100 FUO patients, 50% were found to have infectious diseases, 24% were found to have connective tissue diseases, 8% miscellaneous causes and 7% neoplastic diseases (P < 0.05). In 11 patients no definite cause for FUO could be identified. Connective tissue patients were: eight systemic lupus patients (33.3%), five patients with familial mediterranean fever (20.8%), four patients with rheumatoid arthritis (16.6%), three patients (12.5%) with Still’s disease and Rheumatic fever and one patient with Behçet syndrome/Crohn’s disease (4.3%), (P < 0.05).Conclusions:Despite the advanced technology, FUO remains a challenging medical problem. Infections were the most common cause of FUO in Egypt, confirming the trends found in other parts of the world. There was an increased prevalence of connective tissue patients presented with prolonged unexplained fever. A keen clinical eye, meticulous history taking and repeated physical examination remained the most important diagnostic tools in FUO patients.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin

Abdelbaky

Mansour

Ibrahim

et al. 2011

Clin Med�Insights�Arthritis�Musculoskelet Disord

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“…This report advises that in the elderly population, ulcerative colitis (UC) should be considered as a cause of PUO, even in the absence of gastrointestinal symptoms. In adult populations, Muñoz et al (2007) reported two patients with Crohn's disease who presented with PUO, however both had mild intestinal symptoms and one had polyarthritis [9]. Our case had only short-lived diarrhea and abdominal pain at the onset, but a paucity of gastrointestinal symptoms for the majority of remaining time.…”

Section: Discussionmentioning

confidence: 54%

An Unusual Case of Pyrexia of Unknown Origin

Soliman¹,

Shirazi-Nejad²,

Bullas³

et al. 2021

Cureus

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A previously fit and well 29-year-old man with no significant recent travel or contact history presented to the hospital with 11 days of feeling unwell, intermittent diarrhea, abdominal pain and a skin rash that was consistent with folliculitis. Despite resolution of these index symptoms he continued with recurring fever of 38.5 degrees centigrade and weight loss of six Kilograms over the next three weeks. Extensive investigations to find a cause for the unexplained persistent fever failed to reveal an etiology, hence fulfilling pyrexia of unknown origin definition (PUO). None of the three main causes of PUO, namely infections, autoimmune diseases or underlying malignancy, were confidently found. Colonoscopy was suggested following a review of the abdominal CT scan to investigate possible thickening of the bowel wall. A diagnosis of atypically presenting Crohn's disease was eventually made and confirmed by colonoscopy and histology. The fever responded promptly to treatment of the Crohn's disease and he remained well at follow-up at six and 12 months after the initial presentation. In conclusion, it is important to keep in mind that PUO can be a rare initial presentation of inflammatory bowel disease in young adults with little or no gastrointestinal symptoms.

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Inflammatory bowel diseases presenting as pyrexia of unknown origin without bowel symptoms: A case series

Patel,

Patel

et al. 2024

Indian J Gastroenterol

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Enfermedad de Crohn: ¿todavía hoy causa de fiebre de origen desconocido clásica?

Cited by 3 publications

References 0 publications

Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin

Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin

An Unusual Case of Pyrexia of Unknown Origin

Inflammatory bowel diseases presenting as pyrexia of unknown origin without bowel symptoms: A case series

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