Enfermedad de Still del adulto con manifestaciones cutáneas atípicas

Fernández‐Guarino, M.; González, Carmen; Ruiz, Aurelio; Pulido, Martínez; Castaño, A. Harto; Olásolo, Pedro Jaén

doi:10.1016/s0001-7310(06)73473-1

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…The atypical skin eruption was the presenting finding in 3 cases 18,20 while it was reported to appear concurrently with systemic symptoms in the majority of cases. 7,[10][11][12][13][14][15][16][17]20,21 In these latter cases, atypical skin rash appeared as soon as 1 week 18 and as late as 5 months 10 after the classic symptoms of Still disease.…”

Section: Literature Review Of Clinical Presentations In Patients Withmentioning

confidence: 99%

“…7,[10][11][12][13][14][15][16][17]20,21 In these latter cases, atypical skin rash appeared as soon as 1 week 18 and as late as 5 months 10 after the classic symptoms of Still disease. The duration of the atypical eruption before presentation for evaluation ranged from 2 to 3 weeks 14,16,20 to 1 year. 7 Descriptors for the color of the atypical eruption varied from erythematous or brown in the majority of cases to, less commonly, violaceous.…”

Section: Literature Review Of Clinical Presentations In Patients Withmentioning

confidence: 99%

“…10 Chest radiography, positron emission tomography, lymph node biopsy, and bone marrow biopsy were pursued in select cases, 7-10,12,14-16,18,21 and a workup for malignancy was not described in 5 articles. 11,13,17,19,20 The skin rash commonly resolved rapidly and permanently with the use of prednisone, 8,10,12,14,15,19,21 prednisolone, 7,9,16 or intravenous pulsed methylprednisolone. 10,12,14,18 However, some patients required more potent or maintenance immunotherapy with systemic agents, including hydroxychloroquine, cyclosporine, methotrexate, anakinra, or tocilizumab (present article) to control or manage symptoms of Still disease, such as relapsing skin eruptions, fever, or arthralgias.…”

Section: Literature Review Of Clinical Presentations In Patients Withmentioning

confidence: 99%

“…2 Recently, small studies and case reports have described an atypical, persistent skin rash consisting of pruritic papules and plaques with various configurations with distinct histopathology in patients with active AOSD. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] This atypical rash often presents in addition to the typical rash but may also be the only skin manifestation, resulting in delayed diagnosis because of under-recognition. In addition to these reports of atypical cutaneous presentations, emerging literature highlights an increasing recognition of malignancy in association with Still disease, sometimes occurring years later.…”

Section: Introductionmentioning

confidence: 99%

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Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Sun

Brezinski

Berliner

et al. 2015

Journal of the American Academy of Dermatology

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Section: Literature Review Of Clinical Presentations In Patients Withmentioning

confidence: 99%

Section: Literature Review Of Clinical Presentations In Patients Withmentioning

confidence: 99%

Section: Literature Review Of Clinical Presentations In Patients Withmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Sun

Brezinski

Berliner

et al. 2015

Journal of the American Academy of Dermatology

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“…5 In addition to the typical rash, persistent papular lesions on face, neck and upper and lower back are also reported. 6 Pruritic edematous erythemas with persistent plaques are reported in other patients, mainly on the trunk. These lesions persist even when the fever disappeared and show prominent linear pigmentation .…”

Section: Discussionmentioning

confidence: 99%

Oral mucosa lesions as atypical manifestation of adult-onset Still´s disease

Brance

Neffen²

2018

An. Bras. Dermatol.

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Adult-onset Still's disease is a systemic inflammatory disorder of unknown etiology, characterized by skin rash, spiking fever, arthralgias or arthritis, and leukocytosis. The typical skin rash is evanescent, salmon-pink, nonpruritic and maculopapular, predominantly on the extremities. It is considered one of the major Yamaguchi's criteria in adult-onset Still's disease. However, atypical skin lesions are also described. Here, a 61-year-old woman with sore throat, spiking fever, polyarthritis and evanescent salmon-pink nonpruritic maculopapular skin rash on the extremities was diagnosed with adult-onset Still's disease. In addition, atypical brown macules on oral mucosa, localized on the inner lips and tongue were also observed. Biopsy revealed a neutrophilic infiltrate. Despite treatment and improvement of the adult-onset Still's disease, the atypical oral mucosal lesions persisted.

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Adult-onset Still’s disease: a report of 28 cases and review of the literature

et al. 2008

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Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. It is characterized by fever, skin rash, polyarthralgias or polyarthritis, sore throat, hepatosplenomegaly, lymphadenopathy, leukocytosis, liver enzyme elevation, and high serum level of ferritin. Several kinds of skin lesions have been reported in this condition. The aim of this study was to assess the clinical and laboratory aspects of 28 patients with AOSD in central Iran. According to the diagnostic criteria of AOSD, we identified 28 patients between 2002 and 2007. We intended to describe the clinical characteristics, treatment, and outcome of our patients with AOSD. Of 28 patients with AOSD, 21 (75%) were female, 7 (25%) were male. Fever (100%), sore throat (92%), Arthralgia (92%), dermatographism (92%), typical rash (85%) and arthritis (60%) were the most common findings. The mean values of laboratory findings were as follows; C-reactive protein (CRP) level of 14.4 mg/dl, erythrocyte sedimentation rate (ESR) of 91.5 mm/h, leukocyte count of 15744.4/microl. Abnormal levels of aspartate aminotransferase and alanine aminotransferase were observed in 25 (89%) patients. Twenty patients (71%) had high ferritin values (>500 ng/ml). The clinical characteristics were similar to previous series. A febrile polyarthritis was the most frequent presentation form. Dermatographism was frequently encountered phenomenon in our patients with AOSD. Being that dermatographism is a simple inducible skin reaction, along with its sensitivity in active disease, we suggest more controlled studies to validate accuracy and positive predictive value of it in convenient clinical setting in the diagnosis of AOSD and to consider including it in diagnostic criteria.

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Enfermedad de Still del adulto con manifestaciones cutáneas atípicas

Cited by 7 publications

References 8 publications

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

Oral mucosa lesions as atypical manifestation of adult-onset Still´s disease

Adult-onset Still’s disease: a report of 28 cases and review of the literature

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