Enfermedades Diarreicas Agudas asociadas a Rotavirus

Abstract

Acute diarrhea diseases associated to Rotavirus In the period of 2001-2002, a total of 1163 fecal samples were collected from children less than five years of age with diarrhea, at the Hospital Albina Patiño and other health centers in Cochabamba city. Rotavirus infection general prevalence was 19% (220), distributed among hospitalized children 24% (77) and outpatients 17% (143). Rotavirus infections were observed along the whole study period, with highest prevalence in coldest months: April (24%), May (34%) and June (28%) and lowest frequencies (8-15%) in February, August, and September. Major rotavirus outbreak was significantly associated with the driest and colder season. The highest percentage of rotavirus infections (36,3%) was found among children between 7-12 months of age. Moderate dehydration, vomits and fever were the clinical symptoms more frequently associated with rotavirus acute gastroenteritis, being dehydration more common in hospitalized patients. The distribution of P and G genotypes analyzed by RT-PCR was: G1 (44%), G2 (6%), P[8] (24%) and P4 (15%). A co-infection P[8]P[6] was observed in 3 samples (4%). Genotype P[6] was found associated to outpatients. These findings, highlight that rotavirus is an important cause of acute gastroenteritis and that any of the currently available vaccines would potentially be protective against circulating strains found in the city of Cochabamba.

Prevalence and molecular typing of rotavirus in children with acute diarrhoea in Northeastern Colombia

“…In 2012, the national laboratory in Colombia reported that G3 genotypes account only for 3.8% of the total genotypes isolated in the country 20 . Our results show a high proportion of G3P[8] strains (Table 3) that may suggest the potential of strain divergence, as has been previously reported in other Latin American countries 39 and in Europe 40 . Previous surveillance studies in Colombia did not identify any specific patterns in strain prevalence that support the “strain replacement hypothesis” after the introduction of the monovalent rotavirus vaccine 20 .…”

Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia

“…The literature describing the burden of rotavirus in Bolivia has demonstrated the effectiveness of rotavirus vaccine in the region. 5,6,14,16,17 Seven years before vaccine introduction at this study site, rotavirus was detected by PCR in 24% of 317 children aged < 5 years hospitalized with AGE. 17 Rotavirus prevalence was 36% when children < 2 years were analyzed separately, nearly double the prevalence described here (19%).…”

“…5,6,14,16,17 Seven years before vaccine introduction at this study site, rotavirus was detected by PCR in 24% of 317 children aged < 5 years hospitalized with AGE. 17 Rotavirus prevalence was 36% when children < 2 years were analyzed separately, nearly double the prevalence described here (19%). A study conducted at the same institution during peak rotavirus season in the year before and after vaccine introduction demonstrated a fall from 37% to 22% of rotavirus positivity in children < 12 months with AGE.…”

“…Circulating genotypes of each virus are described and rotavirus data published from the same hospital before vaccine introduction are compared with current results. 16,17 …”

Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children

“…In 1989, a study by Lopez et al in Cochabamba, Bolivia, described that rotavirus was found in 22.5% of cases admitted for acute diarrhoeal disease [7]. More recently, a study conducted in 2007 also in Cochabamba, confirmed the high frequency (19%) of rotavirus in children admitted for acute diarrhoea [8]. …”