Enfermedades pleuropulmonares asociadas con la inhalación de asbesto. Una patología emergente

BackgroundAsbestos is a first level carcinogen. However, few epidemiological studies analyse the risk and protective factors associated with asbestos-related diseases and follow up these conditions in the general population. Pleural mesothelioma, caused by inhalation of asbestos fibres at work, at home or in the environment, is the most representative asbestos-related disease.The objectives of this study are to analyse the risk and protective factors associated with asbestos-related diseases and to investigate the incidence of new clinical manifestations in patients already diagnosed with some form of ARD.Methods/DesignWe have designed a matched case–control study with follow up of both cohorts from a population of a health district of the Barcelona province that has been exposed to asbestos for a period of 90 years.DiscussionA better understanding of asbestos-related diseases should improve i) the clinical and epidemiological follow up of patients with this condition; ii) the design of new treatment strategies; iii) and the development of preventive activities. At the end of the study, the two cohorts created in this study (affected cases and healthy controls) will constitute the basis for future research.

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“…As a result of these properties, asbestos is used in a wide range of applications in almost every industrial sector [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with asbestos-related diseases: a community-based case–control study

Rosell‐Murphy

Abós‐Herràndiz²,

Olivella³

et al. 2013

BMC Public Health

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“…Thanks to these properties, we find asbestos in over 3,000 different applications in most industrial sectors [1,2]. In Barcelona province, the jobs associated with the highest risk are workers at fibrocement plants, painters, carriers of asbestos materials and construction workers [3].…”

Section: Introductionmentioning

confidence: 99%

“…Asbestos can also spread via the lymphatic system [2]. Once the asbestos fibres are deposited in the lung, cells are destroyed, fibrosis and perialveolar and bronchiolar scarring takes place (pulmonary asbestosis), ultimately causing breathing difficulty.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to its fibrogenic properties, asbestos is a first-level carcinogen [2]. The most accepted oncological model is the dose-response without a safety level [8].…”

Section: Introductionmentioning

confidence: 99%

“…In Spain, around 4% lung cancers cases are related to asbestos work exposure in synergy with tobacco consumption [16]. No association has been found between tobacco consumption and mesothelioma [2]. …”

Section: Introductionmentioning

confidence: 99%

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Prospective study of asbestos-related diseases incidence cases in primary health care in an area of Barcelona province

et al. 2010

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BackgroundAsbestos related diseases include a number of conditions due to inhalation of asbestos fibres at work, at home or in the environment, such as pleural mesothelioma, asbestosis and calcified pleural plaques. Few epidemiological studies have established the incidence of asbestos related diseases in our area. The present proposal is based on a retrospective study externally funded in 2005 that is currently taking place in the same area and largely carried out by the same research team.The aim of the study is to achieve a comprehensive and coordinated detection of all new cases of Asbestos Related Diseases presenting to primary care practitioners.Methods/designThis is a multicentre, multidisciplinary and pluri-institutional prospective study.Setting12 municipalities in the Barcelona province within the catchment area of the health facilities that participate in the study.SampleThis is a population based study, of all patients presenting with diseases caused by asbestos in the study area.MeasurementsA clinical and epidemiological questionnaire will be filled in by the trained researchers after interviewing the patients and examining their clinical reports.DiscussionData on the incidence of the different Asbestos Related Diseases in this area will be obtained and the most plausible exposure source and space-time-patient profile will be described. The study will also improve the standardization of patient management, the coordination between health care institutions and the development of preventive activities related with asbestos exposure and disease.

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Trace elements in hazardous mineral fibres

Bloise

Barca

Gualtieri

et al. 2016

Environmental Pollution

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Both occupational and environmental exposure to asbestos-mineral fibres can be associated with lung diseases. The pathogenic effects are related to the dimension, biopersistence and chemical composition of the fibres. In addition to the major mineral elements, mineral fibres contain trace elements and their content may play a role in fibre toxicity. To shed light on the role of trace elements in asbestos carcinogenesis, knowledge on their concentration in asbestos-mineral fibres is mandatory. It is possible that trace elements play a synergetic factor in the pathogenesis of diseases caused by the inhalation of mineral fibres. In this paper, the concentration levels of trace elements from three chrysotile samples, four amphibole asbestos samples (UICC amosite, UICC anthophyllite, UICC crocidolite and tremolite) and fibrous erionite from Jersey, Nevada (USA) were determined using inductively coupled plasma mass spectrometry (ICP-MS). For all samples, the following trace elements were measured: Li, Be, Sc, V, Cr, Mn, Co, Ni, Cu, Zn, As, Rb, Sr, Y, Sb, Cs, Ba, La, Pb, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Th, U. Their distribution in the various mineral species is thoroughly discussed. The obtained results indicate that the amount of trace metals such as Mn, Cr, Co, Ni, Cu and Zn is higher in anthophyllite and chrysotile samples, whereas the amount of rare earth elements (REE) is higher in erionite and tremolite samples. The results of this work can be useful to the pathologists and biochemists who use asbestos minerals and fibrous erionite in-vitro studies as positive cyto- and geno-toxic standard references.

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Enfermedades pleuropulmonares asociadas con la inhalación de asbesto. Una patología emergente

Cited by 9 publications

References 75 publications

Risk factors associated with asbestos-related diseases: a community-based case–control study

Risk factors associated with asbestos-related diseases: a community-based case–control study

Prospective study of asbestos-related diseases incidence cases in primary health care in an area of Barcelona province

Trace elements in hazardous mineral fibres

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