“…However, it is also required for the development and function of other cell types, including hematopoietic stem cells (Iwasaki et al, 2005), multipotent progenitors (Wontakal et al, 2011), myeloid cells (Ghani et al, 2011) and B cells (Houston et al, 2007). Forced overexpression of PU.1 can divert early T cells to a myeloid lineage (Anderson et al, 2002;Dionne et al, 2005;Lefebvre et al, 2005;Laiosa et al, 2006b). However, in the context of T-cell development the progenitors are normally protected from diversion, even while expressing high levels of PU.1, by their exposure to Notch signaling from the environment (Franco et al, 2006;Laiosa et al, 2006b) (Fig.…”