As states have begun administering COVID-19 vaccines to those 65 years and older and essential workers, they face substantial challenges. These challenges include the race against more contagious virus variants; the continuing death toll, particularly in vulnerable subgroups 1 ; concerns about vaccine supplies; and insufficient funding for vaccine distribution. The National Academy of Medicine and the Centers for Disease Control and Prevention's Advisory Council On Immunization Practices (ACIP) have emphasized the need for equitable vaccine allocation and urgent prioritization of subgroups most negatively affected by COVID-19.Because of social distancing measures, vaccine scheduling has predominantly relied on technology such as mobile apps and internet portals. Despite ongoing efforts to ensure equity, longstanding systemic disparities in technology access and literacy are hindering equitable vaccine distribution and raising bigger questions about how technology disparities may be affecting social and health disparities. A recent JAMA editorial offered several important recommendations to promote equity in the distribution of COVID-19 vaccines. 2 However, national guidelines and expert recommendations have not proposed solutions to technology-related equity challenges.Ameliorating these inequities will require a deeper understanding of how technology may exacerbate disparities in vaccine access and to consider potential solutions. 3 Author affiliations and article information are listed at the end of this article.