Engagement of Back Remodeling of Adult Neurons in Memory Formation on Rats

Abstract

The article concerns the problem of mechanisms of memory formation. The study was conducted on polyclonal antibodies to serotonin-modulating anticonsolidation protein (SMAP) that is in linear relationship with serotonin. Intra-cerebral administration of polyclonal anti-SMAP antibodies significantly enhanced elaboration and strengthened memory formation in two complex behavioral conditioned models. At the same time, intra-cerebral administration of these antibodies brought to upregulation of nerve growth factor (NGF) in the hippocampus (p<0.001). Intra-cerebral administration of antibodies to dihydropyrimidinase-related protein 2 (active component of SMAP, two other component proteins – tubulin and actin – are structural proteins lacking any regulatory activity) brought to downregulation of beta III tubulin (marker of differentiated neurons) in the hippocampus (p<0.001) and in the left parietal cortex (p<0.01). The obtained results indicate to the process of back remodeling of mature nerve cells of adult organisms occurring under the effects of anti-SMAP and anti-DRP2 antibodies. Conclusion is made that back remodeling (dedifferentiation) of mature nerve cells, apparently, is engaged in memory formation.