Engagement of CD30 shapes the secretion of cytokines by human γ δ T cells

Biswas, Priscilla; Rovere, Patrizia; Filippi, Camilla De; Heltai, Silvia; Smith, Craig R.; Dagna, Lorenzo; Poli, Guido; Manfredi, Angelo A.; Ferrarini, Marina

doi:10.1002/1521-4141(2000)30:18<2172::aid-immu2172>3.0.co;2-5

Cited by 7 publications

(13 citation statements)

References 24 publications

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“…However, CD30 costimulation has been shown to enhance transcription and cytokine production of both IL-4 and IFN-c in TCR-activated cd T cells [72]. Moreover, CD30 signalling, which prolonged the calcium flux induced by TCR activation, appeared to have a selective effect on cytokine production, but not on cd T cell survival or proliferation [72].…”

Section: Regulation Of Cytokine Production By Cd30 Costimulationsupporting

confidence: 92%

“…Consistent with earlier studies on ab T cells [65], high levels of CD30 expression in human cd T cells were linked to a Th2-like cytokine profile [71][72][73]. However, CD30 costimulation has been shown to enhance transcription and cytokine production of both IL-4 and IFN-c in TCR-activated cd T cells [72].…”

Section: Regulation Of Cytokine Production By Cd30 Costimulationmentioning

confidence: 99%

“…4-1BB is expressed on a variety of murine and human cd T cell subsets [72] (our unpublished data), whereas OX40 is upregulated following phosphoantigen activation of Vc9Vd2 T cells, with up to 90% of cells expressing OX40 after a few days in culture [40]. However, the functional implication of these coreceptors in cd T cell activation is still unknown.…”

Section: Other Tnfr Superfamily Coreceptorsmentioning

confidence: 99%

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Searching for “signal 2”: costimulation requirements of γδ T cells

Ribot

deBarros

Silva‐Santos

2011

Cell. Mol. Life Sci.

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T cell activation requires the integration of signals that arise from various types of receptors. Although TCR triggering is a necessary condition, it is often not sufficient to induce full T-cell activation, as reflected in cell proliferation and cytokine secretion. This has been firmly demonstrated for conventional αβ T cells, for which a large panel of costimulatory receptors has been identified. By contrast, the area remains more obscure for unconventional, innate-like γδ T cells, as the literature has been scarce and at times contradictory. Here we review the current state of the art on the costimulatory requirements of γδ T cell activation. We highlight the roles of members of the immunoglobulin (like CD28 or JAML) or tumour necrosis factor receptor (like CD27) superfamilies of coreceptors, but also of more atypical costimulatory molecules, such as NKG2D or CD46. Finally, we identify various areas where our knowledge is still markedly insufficient, hoping to provoke future research on γδ T cell costimulation.

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Section: Regulation Of Cytokine Production By Cd30 Costimulationsupporting

confidence: 92%

Section: Regulation Of Cytokine Production By Cd30 Costimulationmentioning

confidence: 99%

Section: Other Tnfr Superfamily Coreceptorsmentioning

confidence: 99%

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Searching for “signal 2”: costimulation requirements of γδ T cells

Ribot

deBarros

Silva‐Santos

2011

Cell. Mol. Life Sci.

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“…Briefly, 0·5 μg of total RNA extracted from γδ T‐cell clones (1 × 10 6 for each experimental condition) was reverse‐transcribed and the cDNA was amplified with specific primers (Primm s.r.l, Milan, Italy). Primer sequences for IL‐4, IFN‐γ, IL‐8 and the housekeeping gene glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) have been reported 24 . Primer sequences, amplification cycles and product size (base pairs, bp) for CCR1 and CCR2b are the following: CCR1 – forward, 5′‐ACC ATG GAA ACT CCA AAC ACC ACA G, reverse, 5′‐GTC AGA ACC CAG CAG AGA GTT CAT G, 40 cycles, 1100 bp; CCR2b – forward, 5′‐AAC ATG CTG TCC ACA TCT CGT TCT, reverse, 5′‐CGT TTA TAA ACC AGC CGA GAC TTC, 35 cycles, 1100 bp.…”

Section: Methodsmentioning

confidence: 99%

Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on γδ cells

Ferrero¹,

Biswas²,

Vettoretto³

et al. 2003

Immunology

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SUMMARYGranuloma is a typical feature of tuberculosis. We evaluated the chemotaxis of selected human leucocyte subsets induced by macrophages incubated with Mycobacterium tuberculosis (MT)-derived products in vitro. The release of monocyte chemotactic protein 1 (MCP-1) and interleukin-8 (IL-8) correlated with the specific induction of strong chemotaxis towards monocytes and polymorphonuclear leucocytes (PMNs). gd and T helper type 1 (Th1) ab lymphocytes were chemoattracted, while T-resting, IL-2-activated and Th2 lymphocytes were unaffected. Activation with mycobacterium-derived, phosphate-containing components, modulated the chemokine receptor profile of gd T lymphocytes as well as their pattern of cyto-chemokine production, disclosing a potential for their active participation in granuloma formation. In particular, CXCR3 and IP-10, which we found to be released by MT-pulsed alveolar macrophages, seem to represent the receptorcounter-receptor pair implicated in the chemotaxis of gd lymphocytes. Immunohistochemical analysis and in situ hybridization revealed the in vivo presence of IL-8, MCP-1 and IL-10 in lymph node and lung tuberculous granulomas. Our results underscore the role of MT extracts in the induction of macrophage-derived chemokines responsible for the orchestrated recruitment of PMNs, monocytes, and Th1 and gd T cells, as well as in the regulation of gd function.

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“…Increased levels of soluble (s) CD30 have been reported as a CD4-independent predictor of HIV disease evolution [125] indicating that the related cytokine could play an important role in this disease. In addition, engagement of CD30 on γδ T cells induced the release of cytokines and chemokines that can interfere with HIV replication [126]. LT-β upregulated HIV expression in U1 cells independently from NF-kB activation and in synergy with TNF-α [127], whereas there are no information yet on the potential involvement of this cytokine in HIV disease.…”

Section: Tumor Necrosis Factor (Tnf) and Tnf Receptor Family Members mentioning

confidence: 99%

Cytokine and Chemokine Based Control of HIV Infection and Replication

Alfano

Poli

2001

CPD

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HIV infects and propagates into CD4+ T lymphocytes and macrophages, although many other cell types play an important role in virus spreading and pathogenesis. In addition to regulatory viral proteins, the cytokine network has early been implicated as a major controller of the plastic capacity of HIV to spread productively or rather remain silently integrated in the chromosomes of infected cells. The recent discovery of CCR5 and CXCR4 as essential entry co-receptors together with CD4 has highlighted a novel and potentially important step in the pharmacological hunt for more effective antiviral agents. In addition to regulate HIV expression and replication, several cytokines have demonstrated the capacity of up- or down-modulating chemokine receptors including CCR5 and CXCR4 with the consequence of influencing the susceptibility of T cells and macrophages to HIV infection. Pharmacological agents such as pertussis toxin B-oligomer have demonstrated HIV suppressive effects via non competitive binding of CCR5, whereas interferons or interleukin-16 (IL-16) can prevent post-entry steps in HIV expression. At the clinical level, several cytokines or their receptors are useful markers for monitoring disease progression and its consequence on the immune system. Cytokine-based therapy represents a realistic complementary approach to traditional antiretroviral therapy potentially capable of restoring important adaptive or innate immune functions ultimately curtailing HIV spreading and its consequences on the immune system, as exemplified by the experimental clinical use of IL-2.

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Engagement of CD30 shapes the secretion of cytokines by human γ δ T cells

Cited by 7 publications

References 24 publications

Searching for “signal 2”: costimulation requirements of γδ T cells

Searching for “signal 2”: costimulation requirements of γδ T cells

Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on γδ cells

Cytokine and Chemokine Based Control of HIV Infection and Replication

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