Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications

Abstract

Surgical adhesives are playing an important role in wound repair and emergency hemostasis in clinical treatment. However, the development of strong bioglue with rapid in situ adhesion, durable adhesiveness, and flexibility in dynamic and moist physiological environments is still challenging. Herein, a new type of biosynthetic protein bioadhesives with superior adhesion performance is reported by developing a protein aldimine condensation strategy. Lysine‐rich recombinant proteins are designed and massively biosynthesized to instantaneously react with aldehyde cross‐linkers to realize in situ strong adhesion. The obtained bioadhesives show an ultra‐high adhesion strength of ≈101.6 kPa on porcine skin, outperforming extant clinical bioglues. In addition, they possess super biocompatibility, flexibility, biodegradability, and compliance with the tissues. Owing to the strong and instantaneous adhesion properties, the bioadhesives are qualified for dynamic wound closure, facilitating wound repair, and noncompressible hemorrhage. Importantly, they can be industrially encapsulated into custom‐made cartridge delivery tubes at low cost for clinical use. Therefore, biosynthetic bioadhesives have great potential for biological applications and are capable of scaling up to the industrial level for clinical transformation, which will be a successful paradigm for reforming existing clinical products.

Facile Solvent-Free Fabrication of All-Small-Molecule Supramolecular Photothermal Bioadhesive for Sutureless Wound Closure

“…Moreover, the TPFe bioadhesive not only had a certain degree of adhesion on the internal organs of rat (heart, liver, spleen, lungs, and kidneys) but also could adhere firmly to the neck and back of rat without falling off for 4 and 5 days, respectively (Figure S6a,c, Supporting Information). Previous studies have shown that rats moved their necks more frequently, including compression, stretching, and twisting, while their backs were in a relatively static state, so the TPFe bioadhesive stuck to their backs for a longer time . When water was poured into the porcine stomach with a leak, the water would flow out of the hole.…”

“…Previous studies have shown that rats moved their necks more frequently, including compression, stretching, and twisting, while their backs were in a relatively static state, so the TPFe bioadhesive stuck to their backs for a longer time. 40 When water was poured into the porcine stomach with a leak, the water would flow out of the hole. The TPFe bioadhesive was attached to the hole in the porcine stomach, and the porcine stomach was immediately sealed to ensure that the water did not leak out (Figure 3c and Movie S2, Supporting Information).…”