Engineered bio-nanocomposite magnesium scaffold for bone tissue regeneration

Parai, Rohan; Bandyopadhyay‐Ghosh, Sanchita

doi:10.1016/j.jmbbm.2019.04.019

Cited by 54 publications

(30 citation statements)

References 29 publications

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“…In line with the increasing interest in novel biodegradable metallic scaffolds, XCT has shown good potential to evaluate the microarchitecture of Mg-based scaffolds showing both porosity and pore size in the optimal range for bone ingrowth Kang et al, 2019;Parai & Bandyopadhyay-Ghosh, 2019). demonstrate d the capability of XCT to evaluate the corrosion of Mg-based scaffolds over time, enabling the quantification of volume/mass loss and surface degradation.…”

Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 94%

“…In line with the increasing interest in novel biodegradable metallic scaffolds, XCT has shown good potential to evaluate the microarchitecture of Mg‐based scaffolds showing both porosity and pore size in the optimal range for bone ingrowth (Li et al ., ; Kang et al ., ; Parai & Bandyopadhyay‐Ghosh, ). Li et al .…”

Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 99%

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Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Fernández

Witte²,

Tozzi

2019

Journal of Microscopy

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Bone as such displays an intrinsic regenerative potential following fracture; however, this capacity is limited with large bone defects that cannot heal spontaneously. The management of critical‐sized bone defects remains a major clinical and socioeconomic need with osteoregenerative biomaterials constantly under development aiming at promoting and enhancing bone healing. X‐ray computed tomography (XCT) has become a standard and essential tool for quantifying structure–function relationships in bone and biomaterials, facilitating the development of novel bone tissue engineering strategies. This paper presents recent advancements in XCT analysis of biomaterial‐mediated bone regeneration. As a noninvasive and nondestructive technique, XCT allows for qualitative and quantitative evaluation of three‐dimensional (3D) scaffolds and biomaterial microarchitecture, bone growth into the scaffold as well as the 3D characterisation of biomaterial degradation and bone regeneration in vitro and in vivo. Furthermore, in combination with in situ mechanical testing and digital volume correlation (DVC), XCT demonstrated its potential to better understand the bone–biomaterial interactions and local mechanics of bone regeneration during the healing process in relation to the regeneration achieved in vivo, which will likely provide valuable knowledge for the development and optimisation of novel osteoregenerative biomaterials. Lay Description Bone, being a dynamically adaptable material, displays excellent regenerative properties following fracture. However, the self‐healing capacity of bone becomes more difficult with large bone defects. Those defects are common and occur in many clinical situations; hence, biomaterials are mostly used to restore both bone structure and function in the defect site. X‐ray computed tomography (XCT) is a powerful tool to evaluate bone regeneration in critical‐sized defects after the implantation of biomaterials, allowing to an improved understanding of the regeneration process following different bone tissue engineering approaches. This paper focuses on recent advancements in XCT analysis to characterise biomaterial‐mediated bone regeneration in critical‐sized defects. XCT supports three‐dimensional (3D) analysis of biomaterials, scaffolds and regenerated bone microarchitecture, as well as bone ingrowth into the scaffold. As a nondestructive technique, XCT allows for a 3D characterisation of biomaterial degradation and bone regeneration over time. In addition, XCT combined with in situ mechanical experiments and digital volume correlation (DVC) provides a 3D evaluation and quantification of bone–biomaterial interactions and deformation mechanisms during the regeneration process. This remains essential for the development and enhancement of novel biomaterials able to produce bone that is comparable with the native tissue they aim to replace.

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Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 94%

Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 99%

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Fernández

Witte²,

Tozzi

2019

Journal of Microscopy

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“…Then again, cell-relocating and development actuating operators are fused into the implants, which are embedded legitimately into the imperfection territory. Perfect implants ought to be permeable, degradable and non-toxic, and its mechanical characteristic ought to be like those of the host tissue ( Parai and Bandyopadhyay-Ghosh, 2019 ). To get ready permeable grids to be utilized as tissue-designing implants, various techniques, for example, electrospinning, lyophilize, cryogelation and gas frothing, and so on., have been accounted for ( Milazzo et al, 2019 , Nikolova and Chavali, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Cryogel biocomposite containing chitosan-gelatin/cerium–zinc doped hydroxyapatite for bone tissue engineering

Zhang

et al. 2020

Saudi Journal of Biological Sciences

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The present examination includes manufacture and portrayal of cryogel bio-composite implants containing chitosan-gelatin (CS-GT), cerium–zinc doped hydroxyapatite (CS-GT/Ce-Zn-HA) by cryogelation technique. The prepared cryogel biocomposites (CS-GT/HA and CS-GT/Ce-Zn-HA) were described by scanning electron microscope (SEM) and X-Ray diffraction (XRD) contemplates. The expansion of Ce-Zn in the CS-GT implants essentially expanded growing, diminished swelling, expanded protein sorption, and expanded bactericidal movement. The CS-GT/Ce-Zn-HA biocomposite had non-toxic towards rodent osteoblast cells. So the created CS-GT/Ce-Zn-HA biocomposite has favorable and potential applications over the CS-GT/HA platforms for bone tissue engineering.

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“…4 Unlike titanium (Ti), Mg is characterized by its lighter structural composition, with an elastic modulus (42 GPa) and density (1.8 g/cm 3 ), similar to that of native bone. 5 While Mg-alloy based devices are not necessarily novel in the realm of surgical innovation, due to their unfavorable features, such as excessive resorption rate and hydrogen gas production during degradation, have previously rendered them undesirable. 6…”

Section: Introductionmentioning

confidence: 99%

WE43 and WE43-T5 Mg alloys screws tested in-vitro cellular adhesion and differentiation assay and in-vivo histomorphologic analysis in an ovine model

et al. 2020

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WE43 Mg alloy proved to be an ideal candidate for production of resorbable implants in both clinical and trial settings. In previous studies we tested biocompatibility and degradation properties of WE43 (as-cast) and artificially aged (WE43-T5) Mg alloys in a sheep model. Both alloys showed excellent biocompatibility with the as-cast, WE43, form showing increased degradability compared to the artificially aged, WE43-T5. In the present study, our group assessed the biological behavior and degradation pattern of the same alloys when implanted as endosteal implants in a sheep model. Twelve screws (3x15 mm) were evaluated, one screw per each composition was placed bi-cortically in the mandible of each animal with a titanium (2x12 mm) screw serving as an internal positive control. At 6 and 24 weeks histomorphological analysis was performed, at 6 weeks as cast, WE43, yielded a higher degradation rate, increased bone remodeling and osteolysis compared to the WE43-T5 alloy; however, at 24 weeks WE43-T5 showed higher degradation rate and increased bone remodeling than as-cast. In vitro assay of cell growth, adhesion and differentiation was also conducted to investigate possible mechanisms underlying the behavior expressed from the alloys in vivo. In conclusion WE43-T5 indicated bone/implant interaction properties that makes it more suitable for fabrication of endosteal bone screws.

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Engineered bio-nanocomposite magnesium scaffold for bone tissue regeneration

Cited by 54 publications

References 29 publications

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Cryogel biocomposite containing chitosan-gelatin/cerium–zinc doped hydroxyapatite for bone tissue engineering

WE43 and WE43-T5 Mg alloys screws tested in-vitro cellular adhesion and differentiation assay and in-vivo histomorphologic analysis in an ovine model

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