Engineered Biocompatible Nanoparticles for <i>in Vivo</i> Imaging Applications

Chen, Shu; Wang, Lijun; Duce, Suzanne L.; Brown, Stuart I.; Lee, Stephen; Melzer, Andreas; Cuschieri, Sir Alfred; André, Pascal

doi:10.1021/ja106543j

Cited by 94 publications

(98 citation statements)

References 63 publications

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“…35,[38][39][40][41] Furthermore, in the area of medical imaging, FePt NPs are considered to have great potential in MRI and MRI/CT dual-model imaging as a regenerative medicine. 31,33 However, we confirm that there is still a paucity of research on FePt NPs in the radiotherapy field, in which the NPs may hold potential. The current study reports the synthesis of 3.11±0.53 nm monodispersed FePt NPs by a chemical reduction method, and the coating of these NPs …”

Section: Discussionmentioning

confidence: 52%

“…[27][28][29] Furthermore, compared to several commercial MRI/CT contrast agents, the superparamagnetic properties and X-ray absorption abilities of FePt NPs make them potential in vitro and in vivo dual-modality contrast agents (after surface engineering with functional molecules). [30][31][32][33] Based on the extremely high X-ray mass absorption coefficient of Pt, the hypothesis of the current study was that the NPs may increase the absorbed external beam dose in tumors, with decreased absorption of radiation in normal tissue and organs. Therefore, FePt NPs could be the precursor for CT, MRI, chemotherapy and radiotherapy all within one single agent, acting as a kind of multifunctional nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

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FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

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Nanomaterials have an advantage in “personalized” therapy, which is the ultimate goal of tumor treatment. In order to investigate the potential ability of FePt nanoparticles (NPs) in the diagnosis and chemoradiotherapy treatment of malignant tumors, superparamagnetic, monodispersed FePt (~3 nm) alloy NPs were synthesized, using cysteamine as a capping agent. The NPs were characterized by means of X-ray diffraction; transmission electron microscopy, Physical Property Measurement System, and Fourier transform infrared spectroscopy. The cytotoxicity of FePt NPs on Vero cells was assessed using an MTT assay, and tumor cell proliferation inhibited by individual FePt NPs and FePt NPs combined with X-ray beams were also collected using MTT assays; HeLa human cancer cell lines were used as in vitro models. Further confirmation of the combined effect of FePt NPs and X-rays was verified using HeLa cells, after which, the cellular uptake of FePt NPs was captured by transmission electron microscopy. The results indicated that the growth of HeLa cells was significantly inhibited by FePt NPs in a concentration-dependent manner, and the growth was significantly more inhibited by FePt NPs combined with a series of X-ray beam doses; the individual NPs did not display any remarkable cytotoxicity on Vero cells at a concentration <250 μg/mL. Meanwhile, the FePt NPs showed negative/positive contrast enhancement for MRI/CT molecule imaging at the end of the study. Therefore, the combined results implied that FePt NPs might potentially serve as a promising nanoprobe for the integration of tumor diagnosis and chemoradiotherapy.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

View full text Add to dashboard Cite

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“…There are some special kind of nanostructured materials like bio-magnetic nanoparticles which is important to consider the physico-chemical and electro-magnetic properties of nanostructured materials specially MNPs which will be composed at least magnetic element. So, these materials has attracted much interest which has been caused to extend wide range of applications like ferro fluid solutions, magnetic storage devices, bio-sensing application, magnetic power generations and conversion, magnetic controlled drug delivery, magnetic resonance imagining as a contrast agents [61][62][63][64][65][66][67][68][69][70][71][72][73][74]. For biomedical applications, magnetic nanoparticles must (1) have a good thermal stability; (2) larger magnetic moment; (3) be biocompatible; (4) be able to form stable dispersion so the particles could be transported in living system; and (5) well response to AC magnetic fields.…”

Section: Biomedical Applications Of Fe 3 O 4 Magnetic Nanoparticlesmentioning

confidence: 99%

Iron Oxide Biomagnetic Nanoparticles (IO-BMNPs); Synthesis, Characterization and Biomedical Application–A Review

Nochehdehi¹,

Thomas²,

Sadri³

et al. 2017

J Nanomed Nanotechnol

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Nanotechnology is a multidisciplinary branch of science which encompasses numerous diverse fields of science and technology, ranging from biomedical, pharmaceutical, agricultural, environmental, advanced materials, chemical science, physics, electronics, information technology, and so on. Physical and Chemical properties as a major advantages of Nanoparticles can be used in various applications from Industries to medicine. Besides, Magnetic nanoparticles for medical applications have been developed by many researchers. In recent decades, it has received attention by virtue of their potential for applications in different fields. Due to several advantages and widespread applications of magnetic Nanoparticles in biotechnology, medical, material science, engineering, and environmental areas, much attention has been paid to the synthesis of different kinds of Biomagnetic nanoparticles (BMNPs). Core-shell nanoparticles include of coated various materials like: biopolymers (Chitosan, PAA) and bioceramics (Hydroxyapatite) as a shell on top of them and different hard and soft materials like metal oxide (Iron oxide and Cob alt composite) as a core. Improved properties of core-shell nanoparticles like less cytotoxicity, increase biocompatibility, decrease in an interactions with biomolecules, increase physicochemical stability and sort of that, can be due to their use in biological applications. After reviewing several research and review articles and synthesis procedure of Iron based Bio-magnetic Nanoparticles (BMNPs), we should emphasize that, It can be used in different applications like magnetic resonance imaging (MRI), drug delivery systems (DDS), immunoassay, also specially in diagnosis and treatment of cancer via hyperthermia (heat therapy) method.

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“…[16][17][18] The magnetization of FePt NPs up to ∼1000 emu cc −1 is higher than that of commonly used iron oxide (approximately 300-400 emu cc −1 ) and comparable to that of Co (∼1400 emu cc −1 ) and Fe (∼1700 emu cc −1 ), making them valuable candidates for magnetic resonance imaging. [19][20][21][22] It has been reported that FePt NPs display stronger contrast enhancement when compared with several commercial magnetic resonance imaging contrast agents (Feridex, MION, and Sinerem; AMAG Pharmaceuticals Inc., Lexington, MA, MGH Center of Molecular Imaging Research, Boston, MA, and Guerbet Group, Villepinte, France, respectively) according to their apparent transverse relaxivity values. 19,20 Therefore, FePt NPs can serve as dual modality contrast agents for molecular CT (computed tomography molecular imaging or MRI (magnetic resonance imaging) in vitro and in vivo after engineering their surfaces with functional molecules.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22] It has been reported that FePt NPs display stronger contrast enhancement when compared with several commercial magnetic resonance imaging contrast agents (Feridex, MION, and Sinerem; AMAG Pharmaceuticals Inc., Lexington, MA, MGH Center of Molecular Imaging Research, Boston, MA, and Guerbet Group, Villepinte, France, respectively) according to their apparent transverse relaxivity values. 19,20 Therefore, FePt NPs can serve as dual modality contrast agents for molecular CT (computed tomography molecular imaging or MRI (magnetic resonance imaging) in vitro and in vivo after engineering their surfaces with functional molecules. 21 Of particular interest, superparamagnetic FePt NPs have been derived from the anticancer activity of FePt NPs.…”

Section: Introductionmentioning

confidence: 99%

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

Sun¹,

Chen²,

Chen³

et al. 2012

IJN

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Malignant gliomas are primary brain tumors with high rates of morbidity and mortality; they are the fourth most common cause of cancer death. Novel diagnostic and therapeutic techniques based on nanomaterials provide promising options in the treatment of malignant gliomas. In order to evaluate the potential of FePt nanoparticles (NPs) for malignant glioma therapy, FePt NPs with different surface coatings and components were tunably synthesized using oleic acid/oleylamine (OA/OA) and cysteines (Cys) as the capping agents, respectively. The samples were characterized using X-ray diffraction, transmission electron microscopy (TEM), X-ray photon spectroscopy, Fourier transform infrared spectroscopy, atomic absorption spectrum, and zeta potential. The influence of the surface coatings and components of the FePt NPs on the proliferation of glioma cells was assessed through MTT assay and TEM observation using three typical glioma cell lines (glioma U251 cells, astrocytoma U87 cells, and neuroglioma H4 cells) as in vitro models. The results showed that the proliferation of glioma cells was significantly suppressed by lipophilic FePt-OA/OA NPs in a time-and/or dose-dependent manner, while no or low cytotoxic effects were detected in the case of hydrophilic FePt-Cys NPs. The IC 50 value of FePt-OA/OA NPs on the three glioma cell lines was approximately 5-10 µg mL −1 after 24 hours' incubation. Although the cellular uptake of FePt NPs was confirmed regardless of the surface coatings and components of the FePt NPs, the suppression of FePt NPs on glioma cell proliferation was dominantly determined by their surface coatings rather than their components.Therefore, these results demonstrate that, through engineering of the surface coating, FePt NPs can potentially be developed as novel therapeutic agents for malignant gliomas.

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Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications

Cited by 94 publications

References 63 publications

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Iron Oxide Biomagnetic Nanoparticles (IO-BMNPs); Synthesis, Characterization and Biomedical Application–A Review

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

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