Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

Hu, Shichuan; Ma, Jinhu; Su, Chao; Chen, Yanwei; Shu, Yongheng; Qi, Zhongbing; Zhang, Bin; Shi, Gang; Zhang, Yan; Zhang, Yuwei; Huang, Anliang; Kuang, Yueting; Cheng, Ping

doi:10.1016/j.actbio.2021.09.003

Cited by 120 publications

(82 citation statements)

References 48 publications

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“…As a transport carrier of different biological molecules, exosomes along with exosomal active factors (e.g. mRNAs, proteins, miRNAs, and others) are implicated in the modulation of the tumor microenvironment [23,24]. Therefore, the function of exosomes is of considerable interest [25].…”

Section: Discussionmentioning

confidence: 99%

Serum exosomal microRNA-370-3p and microRNA-196a-5p are potential biomarkers for the diagnosis and prognosis of hepatocellular carcinoma

Wei

Zhang

et al. 2022

Folia Histochem Cytobiol.

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Section: Discussionmentioning

confidence: 99%

Serum exosomal microRNA-370-3p and microRNA-196a-5p are potential biomarkers for the diagnosis and prognosis of hepatocellular carcinoma

Wei

Zhang

et al. 2022

Folia Histochem Cytobiol.

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“…Hu et al. constructed exosome-like nanovesicles (eNVs-FAP) from fibroblast activation protein-α (FAP) gene-engineered tumor cells ( 45 ). These nanovesicles facilitated dendritic cell (DC) mature, T cell, and FAP+CAFs infiltration, and depressed the ratio of immunosuppressive M2, myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs).…”

Section: Genetically Engineered Exosomesmentioning

confidence: 99%

Exosome-Based Nanoplatforms: The Emerging Tools for Breast Cancer Therapy

Liu

Zhang

2022

Front. Oncol.

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Breast cancer (BC) remains the leading malignant tumor type among females worldwide. The patients with BC are still faced with undesirable metastasis, relapse rate, and drug resistance. Exosomes are defined as naturally occurring extracellular vesicles (EVs) with typical biomarkers that reflect the characteristics of the parent cells. Exosomes are crucial mediators involved in intercellular communication. By transferring multiple cargoes, represented by proteins, nucleic acids, lipids, metabolites, exosomes contribute to reshaping the recipient cell function and fate. Growing evidence has documented that exosomes originating from BC cells are important participants involved in BC progression and treatments. Nanoparticle-based technology is the cutting-edge field for renewing pharmaceuticals and has endowed deep improvements in precise BC treatment. Additionally, due to their perfect features of the low immune prototype, limited adverse effects, prolongated circulation, and easy modification, exosomes have received much attention as candidates in nano-medicine of BC. The nanoplatforms constructed by exosomes have safety, intelligence, biomimetic, and controlled released advantages for combating BC. Here, we emphasize the multiple exosomes from a variety of cell sources in constructing nanoplatforms for BC therapy, mainly including exosomes and their cargoes, genetically engineered exosomes, and exosome-based carriers. This field would shed light on the promising exosome-based delivery system in BC therapy.

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“…Notably, high exposure to 27-hydroxycholesterol, an abundant circulating cholesterol metabolite, can increase tumorigenic and metastatic capacity that requires sustained expression of GPX4( 96 ). Fibroblast activation protein α (FAP) has been reported to be overexpressed in >90% of types of human cancer ( 97 ). A newly discovered FAP gene-engineered tumor cell-derived exosome-like nanovesicle (eNVs-FAP) vaccine can induce tumor cell ferroptosis to overcome immunosuppression of the tumor microenvironment ( 97 ).…”

Section: The Role Of Pcd In the Metastasis Of Nsclcmentioning

confidence: 99%

“…Fibroblast activation protein α (FAP) has been reported to be overexpressed in >90% of types of human cancer ( 97 ). A newly discovered FAP gene-engineered tumor cell-derived exosome-like nanovesicle (eNVs-FAP) vaccine can induce tumor cell ferroptosis to overcome immunosuppression of the tumor microenvironment ( 97 ). Thus, ferroptosis exhibits promising potential to trigger an anti-cancer immune response ( 98 ).…”

Section: The Role Of Pcd In the Metastasis Of Nsclcmentioning

confidence: 99%

Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

Huang

Lou

et al. 2022

Exp Ther Med

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Non-small cell lung cancer (NSCLC), a common type of cancer worldwide, is normally associated with a poor prognosis. It is difficult to treat successfully as it often metastasizes into brain or bone. Methods to facilitate the induction of effective programmed cell death (PCD) in NSCLC cells to reverse drug resistance, or to inhibit the invasion and migration of NSCLC cells, are currently under investigation. The present study summarized the regulatory functions of PCD, including apoptosis, autophagy and ferroptosis, in the context of NSCLC metastasis. It further summarized how regulatory agents, including long non-coding RNAs, circular RNAs and microRNAs, regulate PCD during the metastasis of NSCLC and characterized new potential diagnostic biomarkers of NSCLC metastasis.

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Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

Cited by 120 publications

References 48 publications

Serum exosomal microRNA-370-3p and microRNA-196a-5p are potential biomarkers for the diagnosis and prognosis of hepatocellular carcinoma

Serum exosomal microRNA-370-3p and microRNA-196a-5p are potential biomarkers for the diagnosis and prognosis of hepatocellular carcinoma

Exosome-Based Nanoplatforms: The Emerging Tools for Breast Cancer Therapy

Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

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