Engineered Functional Surfaces by Laser Microprocessing for Biomedical Applications

Hu, Guiping; Guan, Kai; Lu, Lihua; Zhang, Jiaru; Nie, Li; Guan, Yingchun

doi:10.1016/j.eng.2018.09.009

Cited by 40 publications

(28 citation statements)

References 46 publications

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“…To date, metallic biomaterials include platinum, and gold is increasingly used in medical applications due to their high mechanical strength, long-term stability, good conductivity, and biocompatibility [46]. However, except noble metals, most metallic materials are easily oxidized, and present weak corrosion resistance [47, 48], the release of metal ion may also cause allergies or carcinogenesis. Surface modification of metallic materials is considered to be an effective method to solve the above problems, include preparation of coatings, and covalent chemical conjugation of bioactive molecules [48].…”

Section: Introductionmentioning

confidence: 99%

“…However, except noble metals, most metallic materials are easily oxidized, and present weak corrosion resistance [47, 48], the release of metal ion may also cause allergies or carcinogenesis. Surface modification of metallic materials is considered to be an effective method to solve the above problems, include preparation of coatings, and covalent chemical conjugation of bioactive molecules [48]. Conducting polymers, such as poly (3,4-ethylene dioxythiophene), polyaniline, polypyrrole (PPy) have been studied as possible candidates [49].…”

Section: Introductionmentioning

confidence: 99%

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Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

et al. 2019

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Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

et al. 2019

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“…Daha güncel bir yöntem olan lazerle pürüzlendirme tekniğinde implant yüzeyinin bazı noktalarına yoğun lazer ışını uygulanmaktadır [40,41,[48][49][50][51][52][53][54][55] (Şekil 1-e). Bu şekilde 1 μm veya daha küçük çukurcuklar elde edilebilir.…”

Section: Lazerle Pürüzlendirilmiş Yüzeyler (Laser Etched Surfaces)unclassified

Current Approaches in Surface Processing of Biomedical Alloys; Laser Processes

Gedikoğlu¹,

Kolsal²,

Tutuş³

et al. 2021

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım Ve Teknoloji

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“…However, Ti-6Al-4V is a bioinert biomaterial and its osseointegration ability is not good enough, which may result in implant failure over the long term. To enhance the bioactivity and biocompatibility of titanium alloy implants, surface modification strategies have attempted to mimic the characteristics of bone and trigger specific cellular responses to induce cell adherence, alignment and proliferation [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Bioactivity and Biocompatibility of Bio-Inspired Ti-6Al-4V Alloy Surfaces Modified by Combined Laser Micro/Nano Structuring

Yang

Liu

et al. 2020

Molecules

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The bioactivity and biocompatibility play key roles in the success of dental and orthopaedic implants. Although most commercial implant systems use various surface microstructures, the ideal multi-scale topographies capable of controlling osteointegration have not yielded conclusive results. Inspired by both the isotropic adhesion of the skin structures in tree frog toe pads and the anisotropic adhesion of the corrugated ridges on the scales of Morpho butterfly wings, composite micro/nano-structures, including the array of micro-hexagons and oriented nano-ripples on titanium alloy implants, were respectively fabricated by microsecond laser direct writing and femtosecond laser-induced periodic surface structures, to improve cell adherence, alignment and proliferation on implants. The main differences in both the bioactivity in simulated body fluid and the biocompatibility in osteoblastic cell MC3T3 proliferation were measured and analyzed among Ti-6Al-4V samples with smooth surface, micro-hexagons and composite micro/nano-structures, respectively. Of note, bioinspired micro/nano-structures displayed the best bioactivity and biocompatibility after in vitro experiments, and meanwhile, the nano-ripples were able to induce cellular alignment within the micro-hexagons. The reasons for these differences were found in the topographical cues. An innovative functionalization strategy of controlling the osteointegration on titanium alloy implants is proposed using the composite micro/nano-structures, which is meaningful in various regenerative medicine applications and implant fields.

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Engineered Functional Surfaces by Laser Microprocessing for Biomedical Applications

Cited by 40 publications

References 46 publications

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

Current Approaches in Surface Processing of Biomedical Alloys; Laser Processes

In Vitro Bioactivity and Biocompatibility of Bio-Inspired Ti-6Al-4V Alloy Surfaces Modified by Combined Laser Micro/Nano Structuring

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