Engineered hydrogels for peripheral nerve repair

Yao, Lina; Zhang, Xiaonong; Xiao, Chunsheng; Liu, Bin

doi:10.1016/j.mtbio.2023.100668

Cited by 17 publications

(11 citation statements)

References 229 publications

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“…Patients with peripheral nerve injury develop painful neuropathy and neuroma, poor sensation, weakness, and paralysis following traumatic, nontraumatic, and iatrogenic experiences. These pathologies are derived from motor and sensory axon damage and loss of function [ 59 ]. Although the peripheral nervous system is more easily regenerated than the central nervous system, the clinical repair of peripheral nerve injury is still not satisfactory [ 60 ].…”

Section: The Nervous Systemmentioning

confidence: 99%

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Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

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The repair of nervous tissue is a critical research field in tissue engineering because of the degenerative process in the injured nervous system. In this review, we summarize the progress of injectable hydrogels using in vitro and in vivo studies for the regeneration and repair of nervous tissue. Traditional treatments have not been favorable for patients, as they are invasive and inefficient; therefore, injectable hydrogels are promising for the treatment of damaged tissue. This review will contribute to a better understanding of injectable hydrogels as potential scaffolds and drug delivery system for neural tissue engineering applications.

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Section: The Nervous Systemmentioning

confidence: 99%

“…Tissue engineering allows to produce nerve conduits biocompatible with soft biomechanical structures and suitable flexibility. Also, scaffolds should mimic the natural extracellular matrix surrounding the nerve [ 59 , 108 ].…”

Section: Repair Of Nervous Tissue By Injectable Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

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“…The utilization of hydrogels as drug delivery systems, sustained release platforms, or biotherapeutic scaffolds for tissue regeneration showcases their exceptional potential in the field (see Table ). − Effective management of early inflammation in periodontitis necessitates precise and sustained drug release for immune modulation during the pathogenesis and progression of the disease. Reconstruction of periodontal tissues in late severe periodontitis requires an incubation platform that facilitates cell proliferation and differentiation .…”

Section: The Role Of Hydrogel In the Treatment Of Periodontitismentioning

confidence: 99%

Advances in Hydrogels for Periodontitis Treatment

Li,

Wang,

Xiao

et al. 2024

ACS Biomater. Sci. Eng.

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Periodontitis is a common condition characterized by a bacterial infection and the disruption of the body's immune-inflammatory response, which causes damage to the teeth and supporting tissues and eventually results in tooth loss. Current therapy involves the systemic and local administration of antibiotics. However, the existing treatments cannot exert effective, sustained release and maintain an effective therapeutic concentration of the drug at the lesion site. Hydrogels are used to treat periodontitis due to their low cytotoxicity, exceptional water retention capability, and controlled drug release profile. Hydrogels can imitate the extracellular matrix of periodontal cells while offering suitable sites to load antibiotics. This article reviews the utilization of hydrogels for periodontitis therapy based on the pathogenesis and clinical manifestations of the disease. Additionally, the latest therapeutic strategies for smart hydrogels and the main techniques for hydrogel preparation have been discussed. The information will aid in designing and preparing future hydrogels for periodontitis treatment.

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“…They have three major components: (1) the cell body, where essential cell functions are performed, (2) the dendrites, which receive signals at the synapse, and (3) the axon, which acts as a cable to transmit electrical signals to the next synapse. The axon is typically covered by a myelin sheath, comprising lipids and proteins, to protect the axon and conduct electrical signals [ 16 ]. The myelinated axons, also called nerve fibers, vary in diameter from 0.2 to 20 µm, depending on their function and location [ 17 ], and are surrounded by the basal lamina.…”

Section: Physicochemical Properties and Regeneration Capacity Of Peri...mentioning

confidence: 99%

Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration

Mankavi,

Ibrahim,

Wang

2023

Nanomaterials

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Injuries to the peripheral nervous system are a common clinical issue, causing dysfunctions of the motor and sensory systems. Surgical interventions such as nerve autografting are necessary to repair damaged nerves. Even with autografting, i.e., the gold standard, malfunctioning and mismatches between the injured and donor nerves often lead to unwanted failure. Thus, there is an urgent need for a new intervention in clinical practice to achieve full functional recovery. Nerve guidance conduits (NGCs), providing physicochemical cues to guide neural regeneration, have great potential for the clinical regeneration of peripheral nerves. Typically, NGCs are tubular structures with various configurations to create a microenvironment that induces the oriented and accelerated growth of axons and promotes neuron cell migration and tissue maturation within the injured tissue. Once the native neural environment is better understood, ideal NGCs should maximally recapitulate those key physiological attributes for better neural regeneration. Indeed, NGC design has evolved from solely physical guidance to biochemical stimulation. NGC fabrication requires fundamental considerations of distinct nerve structures, the associated extracellular compositions (extracellular matrices, growth factors, and cytokines), cellular components, and advanced fabrication technologies that can mimic the structure and morphology of native extracellular matrices. Thus, this review mainly summarizes the recent advances in the state-of-the-art NGCs in terms of biomaterial innovations, structural design, and advanced fabrication technologies and provides an in-depth discussion of cellular responses (adhesion, spreading, and alignment) to such biomimetic cues for neural regeneration and repair.

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Engineered hydrogels for peripheral nerve repair

Cited by 17 publications

References 229 publications

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Advances in Hydrogels for Periodontitis Treatment

Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration

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