Engineered in-situ depot-forming hydrogels for intratumoral drug delivery

Fakhari, Amir; Subramony, J. Anand

doi:10.1016/j.jconrel.2015.11.014

Cited by 148 publications

(104 citation statements)

References 123 publications

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“…Among various delivery vectors, including liposomes, 1, 2 polymersomes, 3, 4 niosomes, 5 micelles, 6 hydrogels, 7 dendrimers, 8, 9 etc ., liposomes are one of the most successful 10 in the commercial market, because of their simplicity, biocompatibility, biodegradability, the enhancement on drug efficacy, etc . There are 12 liposomal formulations that have been approved for clinical applications as of 2012, including Doxil ® , Caelyx ® , Myocet ® , DaunoXome ® , Visudyne ® , Ambisome ® , DepoDur ® , loading therapeutic agents, such as doxorubicin, daunorubicin, amphotericin B, verteporfin, or morphine, to enhance their delivery to the targeted tissue.…”

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confidence: 99%

Design and Characterization of a Therapeutic Non-phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics To Promote Bone Formation

et al. 2017

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Sterosomes are a recently developed type of non-phospholipid liposomes formed from single-chain amphiphiles and high content of sterols. Although sterosomes presented significantly increased stability compared to conventional phospholipid liposomes, current sterosome biomaterials are not truly bioactive and have no intrinsic therapeutic effects. The purpose of this study was to develop a sterosome formulation with osteoinductive properties by an effective selection of sterol, one of the sterosome components. Oxysterols are oxidized derivatives of cholesterol and are known to stimulate osteogenesis and bone formation. Thus, 20S-hydroxycholesterol (Oxy), one of the most potent oxysterols for bone regeneration was examined as a promising candidate molecule to form fluid lamellar phases with a single-chain amphiphile, namely stearylamine (SA). First, the optimal composition was identified by investigating the phase behavior of SA/Oxy mixtures. Next, the capacity of the optimized SA/Oxy sterosomes to promote osteogenic differentiation of bone marrow stromal cells was assessed in vitro in a hydrogel environment. Furthermore, we explored the effects of osteogenic oxysterol sterosomes in vivo with the mouse critical-sized calvarial defect model. Our results showed that SA/Oxy sterosomes induced osteogenic differentiation in vitro and enhanced calvarial healing without delivery of additional therapeutic agents, indicating their intrinsic bone forming potential. This study suggests a promising non-phospholipid liposomal platform with osteoinductive properties for delivery of small molecular drugs and/or other therapeutic genes for enhanced bone formation.

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confidence: 99%

Design and Characterization of a Therapeutic Non-phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics To Promote Bone Formation

et al. 2017

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“…Chitosan and TPP are highly biocompatible and have been applied in regenerative medicine 26 and drug delivery. 27 The positive charges of the NPs promote payload delivery to the negatively charged cell surface. Before the illumination, curcumin was weakly toxic to both GES and MKN45 when the concentration of curcumin was higher than 20 μM, whereas CNP had no dark toxicity ( Figure 3A and C).…”

Section: Cell Viability Before and After Pdt With Various Nanoparticlesmentioning

confidence: 99%

EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles

Tsai¹,

Yu²,

Huang³

et al. 2018

IJN

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Background Photodynamic therapy (PDT) is an effective therapy for cancers and is a minimally invasive therapy with low dark toxicity and limited side effects. PDT employs the combination of photosensitizers with a specific light source to produce reactive oxygen species (ROS) to damage tumor cells. Methods We fabricated nanoparticles encapsulating curcumin through crosslinking chitosan and tripolyphosphate (TPP). Additionally, the chitosan was conjugated to epidermal growth factor in order to target the epidermal growth factor receptor (EGFR), overexpressed on cancer cells. To investigate PDT using fabricated nanoparticles, we measured cell viabilities and ROS production in relation to EGFR-overexpressing gastric cancer cells and non-cancer gastric cells. Results The targeting nanoparticles displayed a superior PDT effect in the cancer cell, with a resultant approximately fourfold decrease in the IC 50 . The PDT mechanism of curcumin-encapsulated nanoparticles is further identified as the generation of 1 O 2 , the major pathway in PDT. Conclusion These curcumin-encapsulated chitosan/TPP nanoparticles are a promising targeted-PDT against EGFR-overexpressing cancers.

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“…These materials include the traditional pharmaceutical excipients approved by the FDA such as natural polymers, a range of synthetic polymers, and phospholipids, but also more exotic systems including hydrogels and even inorganic material such as TiO 2 [41][42][43][44]. Naturally-occurring polymers remain a key focus of research interest because of their abundant supply and relatively environmentally-friendly preparation routes.…”

Section: Introductionmentioning

confidence: 99%

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Yang

et al. 2017

Acta Biomaterialia

123

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Nanosized sustainedrelease drug depots fabricated using modified tri-axial electrospinning, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.01.069 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning Abstract:Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62 ± 0.07 µm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36 h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

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Engineered in-situ depot-forming hydrogels for intratumoral drug delivery

Cited by 148 publications

References 123 publications

Design and Characterization of a Therapeutic Non-phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics To Promote Bone Formation

Design and Characterization of a Therapeutic Non-phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics To Promote Bone Formation

EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

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