Engineered lipid bicelle nanostructures for membrane-disruptive antibacterial applications

Sut, Tun Naw; Valle-González, Elba R.; Yoon, Bo Kyeong; Park, Soo-Hyun; Jackman, Joshua A.; Cho, Nam‐Joon

doi:10.1016/j.apmt.2021.100947

Cited by 8 publications

(4 citation statements)

References 58 publications

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“…While lipid bicelles were originally invented as suitable membrane‐mimetic environments to reconstitute membrane proteins for structural biology studies, [ 186 ] they have also emerged as promising tools for biotechnology applications such as drug delivery, [ 187 ] antibacterial medicine, [ 188 ] and lipid bilayer coatings. [ 189 ] To date, LNPs and lipoplexes are the most advanced types of lipid‐based nanoparticles for nucleic acid delivery applications, but there is growing attention to lipid bicelles.…”

Section: Lipid Bicellesmentioning

confidence: 99%

Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

Ferhan

Park

et al. 2022

Adv Funct Materials

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Lipid-based nanoparticles have emerged as a clinically viable platform technology to deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of the most exciting areas of recent progress and future innovation potential lies in the material science of lipid-based nanoparticles, both to refine existing nanoparticle strategies and to develop new ones. Herein, the latest efforts to develop next-generation lipid-based nanoparticles are covered by taking a nanoarchitectonics perspective and the design, nucleic acid encapsulation methods, scalable production, and application prospects are critically analyzed for three classes of lipid-based nanoparticles: 1) traditional lipid nanoparticles (LNPs); 2) lipoplexes; and 3) bicelles. Particular focus is placed on rationalizing how molecular self-assembly principles enable advanced functionalities along with comparing and contrasting the different nanoarchitectures. The current development status of each class of lipid-based nanoparticle is also evaluated and possible future directions in terms of overcoming clinical translation challenges and realizing new application opportunities are suggested.

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Section: Lipid Bicellesmentioning

confidence: 99%

Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

Ferhan

Park

et al. 2022

Adv Funct Materials

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“…In addition to encapsulating fatty acids in liposomal formulations, there has also been recent exploration of bicellar nanostructures to encapsulate monoglycerides. Sut et al reported the fabrication of lipid bicelles composed of 1,2-dioleoyl- sn -glycero-3-phosphocholine (DOPC) phospholipid and glycerol monolaurate (GML), which exhibited membrane-disruptive activity that was distinct from that of free GML [ 50 ]. The specific ratio of DOPC and GML components influenced the type and extent of membrane-disruptive activity and particular focus was placed on pore-forming lipid bicelles composed of DOPC and GML in a 1:4 molar ratio.…”

Section: Application Examplesmentioning

confidence: 99%

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan

Yoon

Cho

et al. 2021

IJMS

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There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

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“…It also causes some oxidative damage in rabbit myocardial tissue. , Moreover, PT as a kind of biocide can interact with common biomolecules, such as phosphatidyl-ethanolamine and cysteine . It also reduces ATP levels in bacteria significantly. , Pyrithione is a bidentate ligand that can form neutral and lipophilic metal complexes with divalent and trivalent metal ions through its sulfur and oxygen atoms. − When they bind to metal ions, the complexes significantly enhance their antibacterial ability. Normally, the ligands act as monodentate or bidentate ligands to one metal center, such as sodium(I), zinc(II), and copper(II) ions, to form mononuclear or binuclear complexes NaPT, ZnPT, and CuPT.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Applications of Rare-Earth-Based Complexes with Antibacterial and Antialgal Properties

Li,

Zhu,

et al. 2023

ACS Appl. Bio Mater.

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The pursuit of environmentally friendly and highly effective antifouling materials for marine applications is of paramount importance. In this study, we successfully synthesized novel rare earthbased complexes by coordinating cerium (Ce III), samarium (Sm III), and europium (Eu III) with pyrithione (1-hydroxy-2-pyridinethione; PT). Extensive characterizations were performed, including singlecrystal X-ray analysis, which revealed the intriguing binuclear structure of these complexes. This structural motif comprises two rare-earth ions intricately double-bridged by two oxygen atoms from the PT ligand, resulting in a distinctive and intriguing geometry. Furthermore, the central rare earth ion is surrounded by three sulfur atoms and two additional oxygen atoms, forming a unique distorted bicapped trigonal prismatic configuration. Compared with conventional antifouling biocides such as sodium pyrithione (NaPT), copper pyrithione (CuPT), and zinc pyrithione (ZnPT), these newly synthesized rare-earth complexes exhibited a remarkable boost in their in vitro antibacterial efficacy against both Gram-positive and Gramnegative bacteria. Additionally, these complexes demonstrated significant potential as antialgal agents, displaying impressive activity against marine planktonic organisms. These findings underscore the promising application prospects of these rare-earth complexes in the field of marine antifouling.

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Engineered lipid bicelle nanostructures for membrane-disruptive antibacterial applications

Cited by 8 publications

References 58 publications

Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Synthesis, Characterization, and Applications of Rare-Earth-Based Complexes with Antibacterial and Antialgal Properties

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