Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

Cirujano, Francisco G.

doi:10.1002/cctc.201900131

Cited by 29 publications

(15 citation statements)

References 109 publications

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“…This creates ambiguities in the synthesis and activation processes, and distinguishing active from inactive segregated species is a challenging task. MOFs, as zeolites, present high porosity and crystallinity, which allows characterization by single crystal and/or powder‐diffraction techniques [39–42] . The advantages of MOFs over zeolites are the well‐defined nature of their atomically dispersed active sites (every metal site is endowed with the same nuclearity, oxidation state and coordination environment) and unique electronic properties and reactivity of the metal‐oxo clusters.…”

Section: Supported Sac For Oxidative C−h/c−h Couplingsmentioning

confidence: 99%

Supported Single Atom Catalysts for C−H Activation: Selective C−H Oxidations, Dehydrogenations and Oxidative C−H/C−H Couplings

Martín

Cirujano

2021

ChemCatChem

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The activation of C−H bonds in hydrocarbons (saturated, unsaturated and aromatics) by single atom catalysts immobilized in a solid support is an active research front in catalysis. On the one hand, different examples of transition metal catalysts atomically dispersed on inorganic, organic and hybrid supports are constantly designed, synthesized and characterized using advanced microscopy and spectroscopic techniques. On the other hand, active, selective and stable single metal sites are recently developed as high performant heterogeneous catalysts for the C−H activation of organic molecules. This review covers recent examples of selective alkane and arene C−H oxidations, dehydrogenations of alkanes, as well as C−H/C−H oxidative couplings involving arenes, alkenes and alkynes, based on the use of supported single atom catalysts.

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Section: Supported Sac For Oxidative C−h/c−h Couplingsmentioning

confidence: 99%

Supported Single Atom Catalysts for C−H Activation: Selective C−H Oxidations, Dehydrogenations and Oxidative C−H/C−H Couplings

Martín

Cirujano

2021

ChemCatChem

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“…A straightforward strategy to improve the sustainability of complex chemical synthesis is to consider how nature synthesizes biologically active compounds using enzymatic catalysis. Unfortunately, enzymes that catalyze C-C and C -N bond forming reactions employed in the synthesis of active pharmaceutical ingredients (such as Knoevenagel condensation, Henry reaction, Michael addition, and Friedel-Crafts alkylation) are quite rare [63]. In this regard, chemists have looked into more robust and cost-effective catalytic systems that can be adapted to a broad range of reaction conditions, in order to decrease the production costs of synthesis.…”

Section: Ldh Applications In Organic Catalysismentioning

confidence: 99%

Layered Double Hydroxides: A Toolbox for Chemistry and Biology

et al. 2019

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Layered double hydroxides (LDHs) are an emergent class of biocompatible inorganic lamellar nanomaterials that have attracted significant research interest owing to their high surface-to-volume ratio, the capability to accumulate specific molecules, and the timely release to targets. Their unique properties have been employed for applications in organic catalysis, photocatalysis, sensors, drug delivery, and cell biology. Given the widespread contemporary interest in these topics, time-to-time it urges to review the recent progresses. This review aims to summarize the most recent cutting-edge reports appearing in the last years. It firstly focuses on the application of LDHs as catalysts in relevant chemical reactions and as photocatalysts for organic molecule degradation, water splitting reaction, CO2 conversion, and reduction. Subsequently, the emerging role of these materials in biological applications is discussed, specifically focusing on their use as biosensors, DNA, RNA, and drug delivery, finally elucidating their suitability as contrast agents and for cellular differentiation. Concluding remarks and future prospects deal with future applications of LDHs, encouraging researches in better understanding the fundamental mechanisms involved in catalytic and photocatalytic processes, and the molecular pathways that are activated by the interaction of LDHs with cells in terms of both uptake mechanisms and nanotoxicology effects.

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“…Their high surface area and possibility of introducing different types of well-defined active sites (e.g., metals, organic functions or organometallic complexes) resulted in the exponential growth of their catalytic applications over traditional oxides, carbon or polymers [ 2 , 3 , 4 , 5 ]. In particular, the formation of a C–C bonds in the manufacture of high-added-value molecules using MOFs as heterogeneous catalysts is an important research field with applications in the fine chemical and pharmaceutical industries [ 6 , 7 , 8 , 9 ]. Besides the use of MOFs in gas storage [ 10 ], gas separation [ 11 ], sensors [ 12 ], proton conductivity [ 13 ], and chromatographic applications [ 14 ], heterogeneous catalysis is one of the areas that have been explored extensively in the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Metal-Organic Frameworks as Versatile Heterogeneous Solid Catalysts for Henry Reactions

2021

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Metal–organic frameworks (MOFs) have become one of the versatile solid materials used for a wide range of applications, such as gas storage, gas separation, proton conductivity, sensors and catalysis. Among these fields, one of the more well-studied areas is the use of MOFs as heterogeneous catalysts for a broad range of organic reactions. In the present review, the employment of MOFs as solid catalysts for the Henry reaction is discussed, and the available literature data from the last decade are grouped. The review is organized with a brief introduction of the importance of Henry reactions and structural properties of MOFs that are suitable for catalysis. The second part of the review discusses the use of MOFs as solid catalysts for the Henry reaction involving metal nodes as active sites, while the third section provides data utilizing basic sites (primary amine, secondary amine, amides and urea-donating sites). While commenting on the catalytic results in these two sections, the advantage of MOFs over other solid catalysts is compared in terms of activity by providing turnover number (TON) values and the structural stability of MOFs during the course of the reaction. The final section provides our views on further directions in this field.

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Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

Cited by 29 publications

References 109 publications

Supported Single Atom Catalysts for C−H Activation: Selective C−H Oxidations, Dehydrogenations and Oxidative C−H/C−H Couplings

Supported Single Atom Catalysts for C−H Activation: Selective C−H Oxidations, Dehydrogenations and Oxidative C−H/C−H Couplings

Layered Double Hydroxides: A Toolbox for Chemistry and Biology

Metal-Organic Frameworks as Versatile Heterogeneous Solid Catalysts for Henry Reactions

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