Engineered nanocellulose-based hydrogels for smart drug delivery applications

Liu, Shuai; Qamar, Sarmad Ahmad; Qamar, Mahpara; Basharat, Kanta; Bilal, Muhammad

doi:10.1016/j.ijbiomac.2021.03.147

Cited by 72 publications

(32 citation statements)

References 195 publications

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“…In the biomedical field, owing to its biocompatibility, low cytotoxicity, and tunable surface features, it is becoming increasingly popular for the preparation of hydrogels, scaffolds for tissue engineering, and innovative drug delivery systems. Particularly, in the field of drug delivery it can be used as excipient (but also as starting matrix) to prepare NC-based oral, transdermal and local drug delivery systems, which are able to control drug release and improve both drug stability and therapeutic effects [ 33 , 34 , 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Cairone

Garzoli

Menghini³

et al. 2022

Foods

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Kiwi fruit samples (Actinidia deliciosa Planch, cv. Hayward) represent a suitable and good source for fibers obtainment as well as for polyphenolic and carotenoid extraction. With this aim, in this study they were submitted to a double phase extraction to separate insoluble fibers by an organic phase containing lipophilic substances and an hydroalcoholic phase containing polyphenols and soluble fibers. Insoluble fibers could be separated by filtration and sent to be micronized and reused. Hydroalcoholic fractions were then furtherly fractionated by solid-phase extraction. Data coming from the color CIEL*a*b* and the HPLC-DAD analyses of the extracts were compared and correlate with those coming from the SPME-GC/MS analysis of either the finely shredded peels or of the extracts. The obtained extracts were also submitted to anti-radical activity evaluation and anti-Candida activity. Results show that all of the obtained residues are value added products. Hypotheses were also made about the nature and the possible recycle of the obtained purified solid residue.

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Section: Resultsmentioning

confidence: 99%

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Cairone

Garzoli

Menghini³

et al. 2022

Foods

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“…Therefore, it is necessary to modify the nanocellulose with antimicrobial and bioactive properties for these applications. The modified nanocellulose can be used for the delivery of various drugs in biomedical applications [ 136 ].…”

Section: Delivery Of Active Molecules/therapeutic Agentsmentioning

confidence: 99%

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Patil

Patel

Dutta

et al. 2022

Bioactive Materials

111

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Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

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“…Plant extracts contain high phenolic content and reducing sugars and reducing or stabilizing agents [26,111]. Additionally, as mentioned before, increasing drug resistance and nanofibers formation is getting attention for possible antibacterial and drug delivery properties and nanocellulose formation for biodegradability, non-toxicity, and potential physicochemical properties [112]. Yarbrough et at.…”

Section: Nanocrystals Nanofibers and Nanocellulosementioning

confidence: 99%

Enzymes-Assisted Extraction of Plants for Sustainable and Functional Applications

Štreimikytė

Viškelis

2022

IJMS

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The scientific community and industrial companies have discovered significant enzyme applications to plant material. This rise imparts to changing consumers’ demands while searching for ‘clean label’ food products, boosting the immune system, uprising resistance to bacterial and fungal diseases, and climate change challenges. First, enzymes were used for enhancing production yield with mild and not hazardous applications. However, enzyme specificity, activity, plant origin and characteristics, ratio, and extraction conditions differ depending on the goal. As a result, researchers have gained interest in enzymes’ ability to cleave specific bonds of macroelements and release bioactive compounds by enhancing value and creating novel derivatives in plant extracts. The extract is enriched with reducing sugars, phenolic content, and peptides by disrupting lignocellulose and releasing compounds from the cell wall and cytosolic. Nonetheless, depolymerizing carbohydrates and using specific enzymes form and release various saccharides lengths. The latest studies show that oligosaccharides released and formed by enzymes have a high potential to be slowly digestible starches (SDS) and possibly be labeled as prebiotics. Additionally, they excel in new technological, organoleptic, and physicochemical properties. Released novel derivatives and phenolic compounds have a significant role in human and animal health and gut-microbiota interactions, affecting many metabolic pathways. The latest studies have contributed to enzyme-modified extracts and products used for functional, fermented products development and sustainable processes: in particular, nanocellulose, nanocrystals, nanoparticles green synthesis with drug delivery, wound healing, and antimicrobial properties. Even so, enzymes’ incorporation into processes has limitations and is regulated by national and international levels.

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Engineered nanocellulose-based hydrogels for smart drug delivery applications

Cited by 72 publications

References 195 publications

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Enzymes-Assisted Extraction of Plants for Sustainable and Functional Applications

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