2014
DOI: 10.1016/j.jconrel.2014.03.030
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Engineered nanocrystal technology: In-vivo fate, targeting and applications in drug delivery

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Cited by 210 publications
(92 citation statements)
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“…One successful approach to increase the bioavailability of these drugs is nanosizing (Kipp, 2004;Möschwitzer, 2013). By manufacture of nanosized drug crystals, using techniques including ultrasonic crystallization and wet milling (Pawar et al, 2014), drug nanoparticles with increased dissolution rate and subsequently improved bioavailability can be made. These nanocrystals have a drug load of almost 100%, which is far superior to other nanodrug delivery approaches.…”
Section: Introductionmentioning
confidence: 99%
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“…One successful approach to increase the bioavailability of these drugs is nanosizing (Kipp, 2004;Möschwitzer, 2013). By manufacture of nanosized drug crystals, using techniques including ultrasonic crystallization and wet milling (Pawar et al, 2014), drug nanoparticles with increased dissolution rate and subsequently improved bioavailability can be made. These nanocrystals have a drug load of almost 100%, which is far superior to other nanodrug delivery approaches.…”
Section: Introductionmentioning
confidence: 99%
“…These nanocrystals have a drug load of almost 100%, which is far superior to other nanodrug delivery approaches. The particles consist of crystals of almost pure drug and, in order to retain particle stability, a small addition of various ionic and/or polymeric stabilizers, such as poly(vinyl pyrrolidone) (PVP), dioctyl sulfosuccinate and pluronics type triblock copolymers (Pawar et al, 2014;Wu et al, 2011). Nanosizing leads to an increase in the total surface area, which increases the free energy of the system.…”
Section: Introductionmentioning
confidence: 99%
“…One of the major advantages of NCs is that they can be developed for wide range of drugs including drugs insoluble in both organic media and aqueous media (drugs so called 'brick dust drugs' ) [16]. Specific advantages of NCs that make them superior to other polymeric and lipidic nanosized delivery systems are high drug content, industrial applicability, limited use of toxicologically less favorable organic solvents and excipients, enhanced drug stability in gastrointestinal conditions and less variability in bioavailability between fasted and non fasted state [17].…”
Section: Introductionmentioning
confidence: 99%
“…Nanocrystal formulations of poorly soluble drugs such as fenofibrate (TriCor®, Abbott), sirolimus (Rapamune®, Wyeth), and megestrol (Megace ES®, PAR Pharmaceuticals) have been developed for improving their dissolution and in turn improve their bioavailability (16). Nanocrystals as a formulation approach have been widely employed for improving the solubility and dissolution characteristics of poorly soluble drugs (17). Extensive review of literature is available discussing the advantages, development, and evaluation of drug nanocrystals (18,19) over conventional methods of dissolution enhancement such as solid dispersions, amorphization of drug, and co solvency.…”
Section: Introductionmentioning
confidence: 99%