The ever-evolving field of nanotechnology has led to groundbreaking advancements in biomedical science, particularly through the development of hybrid nanomaterials. This chapter explores the synthesis, characterization, and diverse biomedical applications of these materials, which combine the advantageous properties of both organic and inorganic constituents for optimized functionality. The text delves into the use of hybrid nanomaterials in areas such as drug delivery, diagnostics, tissue engineering, and biosensors. A key case study demonstrating the wound-healing applications of silver nanoparticle-loaded nanofibrous scaffolds is included. The chapter also addresses the challenges and ethical considerations associated with the clinical translation of these nanomaterials. Therefore, this chapter serves as a comprehensive guide for readers interested in understanding and harnessing the immense potential of hybrid nanomaterials in biomedical applications.