Engineered olfactory system for in vitro artificial nose

Zhang, Tianshi; Ren, Wenfei; Xiao, Fangfang; Li, Ji‐Guang; Zu, Baiyi; Dou, Xincun

doi:10.1016/j.engreg.2022.09.003

Cited by 8 publications

(9 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The olfactory function of an e‐nose device can be realized through bioelectric effects, chemical and electrochemical reactions, and electrical‐component responses resulting from physical or chemical adsorption based on sensor units with various recognition principles. [ 23 ]…”

Section: Artificial Olfactory and In‐sensor Computing Systemmentioning

confidence: 99%

“…The olfactory function of an e-nose device can be realized through bioelectric effects, chemical and electrochemical reactions, and electrical-component responses resulting from physical or chemical adsorption based on sensor units with various recognition principles. [23] Five classical algorithms are frequently used for gas recognition: principal component analysis (PCA), decision tree, support vector machine (SVM), K-nearest neighbor (KNN), and the Naive Bayesian model (NBM). PCA is a well-known method that has been used extensively in e-nose systems over the past few decades.…”

Section: Artificial Olfactory and In-sensor Computing Systemmentioning

confidence: 99%

“…[ 22 ] In artificial olfactory systems, sensors with specialized capabilities have been minimized to form units of sensor arrays to categorize odors. [ 23 ] Different types of sensors, including metal oxide‐based electrochemical sensors, mass spectrometry, conductive polymers (CPs), surface acoustic waves (SAWs), biomimetic biosensors, optical sensors, and organic dye‐based colorimetric sensors, have also been used in artificial olfactory systems. [ 24 ] The conventional configuration of the olfactory sensory system contains separate sensors, analog‐to‐digital conversion (ADC), memory, and processing units; therefore, the transmission of raw data between the different units causes issues related to energy consumption, time delay, communication bandwidth, and data security and privacy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Three‐Terminal Artificial Olfactory Sensors based on Emerging Materials: Mechanism and Application

Duan

Huang

Feng

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Over the past several years, a variety of hardware-based artificial sensory systems, including artificial skin, electronic noses, and artificial retinas, have attracted considerable research interest in advanced artificial intelligence systems. The integration of sensing and computing functions in single or multiple connected self-adaptive field-effect transistor (FET)-structured sensory devices to implement artificial olfactory systems for in-sensor computing has recently attracted increasing attention. In this review, the development status of FET-based gas sensory devices is focused on. The mechanisms of sensory FET devices, gas-recognition materials, strategies for improving sensing performance, and the integration of sensory devices into the artificial olfactory system are discussed. Finally, the further development of FET-based sensory devices for artificial olfactory systems and their great potential for next-generation intelligent sensory systems are discussed in broad fields such as environmental monitoring, health care, and military industries.

show abstract

Section: Artificial Olfactory and In‐sensor Computing Systemmentioning

confidence: 99%

Section: Artificial Olfactory and In-sensor Computing Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Three‐Terminal Artificial Olfactory Sensors based on Emerging Materials: Mechanism and Application

Duan

Huang

Feng

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…In the past decade, OOC models highlight the importance of a hierarchical multidimensional structure and the use of organoids for the recapitulation of the native nervous system 96 . Other specific models of the nervous system attempt to mimic the bone marrow, 97 nerves, 98,99 and most recently, sensory organs 100,101 …”

Section: Engineering Microphysiological Systemsmentioning

confidence: 99%

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

2023

View full text Add to dashboard Cite

Current biomedical models fail to replicate the complexity of human biology.Consequently, almost 90% of drug candidates fail during clinical trials after decades of research and billions of investments in drug development. Despite their physiological similarities, animal models often misrepresent human responses, and instead, trigger ethical and societal debates regarding their use. The overall aim across regulatory entities worldwide is to replace, reduce, and refine the use of animal experimentation, a concept known as the Three Rs principle. In response, researchers develop experimental alternatives to improve the biological relevance of in vitro models through interdisciplinary approaches. This article highlights the emerging organ-on-a-chip technologies, also known as microphysiological systems, with a focus on models of the vasculature. The cardiovascular system transports all necessary substances, including drugs, throughout the body while in charge of thermal regulation and communication between other organ systems. In addition, we discuss the benefits, limitations, and challenges in the widespread use of new biomedical models. Coupled with patient-derived induced pluripotent stem cells, organon-a-chip technologies are the future of drug discovery, development, and personalized medicine. K E Y W O R D Sbiomedical, microphysiological systems, models, organ-on-a-chip, vasculatureThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

“…[18] For hydrogel based chemical sensors, the change of disperse medium would affect the reaction rate and reaction process, and thus the influence of disperse medium on reaction should be considered while improving the environment stability. [19][20][21][22] Therefore, it is urgent to optimize the intrinsic polymer chains in hydrogels from the point of the construction procedure rather than from the perspective of adding other components into the disperse medium to ensure the hydrogel is stable in open environment.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Hydration Induced Zwitterionic Hydrogel with Open Environment Stability for Chemical Sensing

Zhang

et al. 2023

Advanced Sensor Research

View full text Add to dashboard Cite

Hydrogels with open environment stability are of great significance in the fields of microelectronics, organ regeneration, and hydrogel-based sensors. Although a series of strategies for exploring highly robust hydrogels have been proposed, it is still challenging to improve environmental stability while maintaining the original dispersed medium feature. Here, 1-vinyl-3-butylimidazolium (VBIM) and acrylic acid (AA) are used as the anionic and cationic monomers to prepare zwitterionic hydrogels through the thermal initiation polymerization. The prepared PAA-IL (polyacrylic acid-co-ionic liquid) hydrogel forms a large number of multi-hydration, including hydrogen bonds and ion-dipole interactions with water to inhibit the freezing and volatilization of water, and it possesses good structural stability due to the formation of ion bond self-association through interchain charge interaction. The robust stability of the chemical sensor with PAA-IL hydrogels as the substrate at different pH and temperature verifies the validity of the proposed design strategy. It is expected that the present zwitterionic hydrogel design strategy would shine a light on the exploration of environment-stable hydrogels and hydrogel-based chemical sensors.

show abstract

Engineered olfactory system for in vitro artificial nose

Cited by 8 publications

References 124 publications

Three‐Terminal Artificial Olfactory Sensors based on Emerging Materials: Mechanism and Application

Three‐Terminal Artificial Olfactory Sensors based on Emerging Materials: Mechanism and Application

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

Multi‐Hydration Induced Zwitterionic Hydrogel with Open Environment Stability for Chemical Sensing

Contact Info

Product

Resources

About