Engineered Spindles of Little Molecules Around Electrospun Nanofibers for Biphasic Drug Release

He, Hua; Mian, WU; Zhu, Jingwen; Yang, Yaoyao; Ge, Ruiliang; Yu, Deng‐Guang

doi:10.1007/s42765-021-00112-9

Cited by 85 publications

(63 citation statements)

References 64 publications

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“…The different greyscales in black and white TEM images suggested the structural changes, and the grey level could be influenced by thickness, density, and elements [ 42 ]. In this work, CA was the principal component in the two prepared fibres, and the PEG component in F2–F4 could be ignored due to the few contents.…”

Section: Resultsmentioning

confidence: 99%

Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres

et al. 2022

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Background The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustained–release drug properties are in opposition. Thus, difficulties remain in the simultaneous improve sustained–release drug properties and increase the hydrophilicity of materials. Methods In this work, we proposed a modified triaxial electrospinning strategy to fabricate functional core–shell fibres, which could elaborate design of shell component for manipulating the sustained-release drug. Cellulose acetate (CA) was designed as the main polymeric matrix, whereas polyethylene glycol (PEG) was added as a hydrophilic material in the middle layer. Cur, as a model drug, was stored in the inner layer. Results Scanning electron microscopy (SEM) results and transmission electron microscopy (TEM) demonstrated that the cylindrical F2–F4 fibres had a clear core–shell structure. The model drug Cur in fibres was verified in an amorphous form during the X-ray diffraction (XRD) patterns, and Fourier transformed infrared spectroscopy (FTIR) results indicated good compatibility with the CA matrix. The water contact angle test showed that functional F2–F4 fibres had a high hydrophilic property in 120 s and the control sample F1 needed over 0.5 h to obtain hydrophilic property. In the initial stage of moisture intrusion into fibres, the quickly dissolved PEG component guided the water molecules and rapidly eroded the internal structure of functional fibres. The good hydrophilicity of F2–F4 fibres brought relatively excellent swelling rate around 4600%. Blank outer layer of functional F2 fibres with 1% PEG created an exciting opportunity for providing a 96 h sustained-release drug profile, while F3 and F4 fibres with over 3% PEG provided a 12 h modified drug release profile to eliminate tailing–off effect. Conclusion Here, the functional F2–F4 fibres had been successfully produced by using the advanced modified triaxial electrospinning nanotechnology with different polymer matrices. The simple strategy in this work has remarkable potential to manipulate hydrophilicity and sustained release of drug carriers, meantime it can also enrich the preparation approaches of functional nanomaterials. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres

et al. 2022

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“…After ten years, the unstable atomization region was recorded as a high-frequency jet and curved whipping region. On this basis, the extremely fast stretching/drying process of the working liquid in the electrospinning process was divided into three steps (Taylor cone, linear jet, and unstable region) [ 63 ]. The electrospinning process has three stages.…”

Section: Electrospinningmentioning

confidence: 99%

Electrospun Nanofiber Membranes for Air Filtration: A Review

et al. 2022

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Nanomaterials for air filtration have been studied by researchers for decades. Owing to the advantages of high porosity, small pore size, and good connectivity, nanofiber membranes prepared by electrospinning technology have been considered as an outstanding air-filter candidate. To satisfy the requirements of material functionalization, electrospinning can provide a simple and efficient one-step process to fabricate the complex structures of functional nanofibers such as core–sheath structures, Janus structures, and other multilayered structures. Additionally, as a nanoparticle carrier, electrospun nanofibers can easily achieve antibacterial properties, flame-retardant properties, and the adsorption properties of volatile gases, etc. These simple and effective approaches have benefited from the significate development of electrospun nanofibers for air-filtration applications. In this review, the research progress on electrospun nanofibers as air filters in recent years is summarized. The fabrication methods, filtration performances, advantages, and disadvantages of single-polymer nanofibers, multipolymer composite nanofibers, and nanoparticle-doped hybrid nanofibers are investigated. Finally, the basic principles of air filtration are concluded upon and prospects for the application of complex-structured nanofibers in the field of air filtration are proposed.

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“…In other words, unspinnable fluids can be treated with spinnable fluids simultaneously for the preparation of nanofibers. Thus, these multiple-fluid processes can greatly expand the capability of electrospinning in creating nanofibers, not only from the filament-forming polymers, but also from little molecules [81].…”

Section: Electrospinningmentioning

confidence: 99%

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

Guo

Zhang

et al. 2021

Polymers

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In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures.

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Engineered Spindles of Little Molecules Around Electrospun Nanofibers for Biphasic Drug Release

Cited by 85 publications

References 64 publications

Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres

Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres

Electrospun Nanofiber Membranes for Air Filtration: A Review

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

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