Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine

Han, Han; Chen, Bi-Te; Liu, Yang; Wang, Yi; Xing, Lei; Wang, Hui; Zhou, Tian-Jiao; Jiang, Hu-Lin

doi:10.1016/j.jconrel.2023.12.024

Journal of Controlled Release

2024

DOI: 10.1016/j.jconrel.2023.12.024

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Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine

Han Han,

Bi-Te Chen,

Yang Liu

et al.

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Cited by 9 publications

References 243 publications

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Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy

Li,

Lin,

Han

et al. 2024

Advanced Materials

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Idiopathic pulmonary fibrosis (IPF) is exacerbated by injurious mechanical forces that destabilize the pulmonary mechanical microenvironment homeostasis, leading to alveolar dysfunction and exacerbating disease severity. However, given the inherent mechanosensitivity of fibrotic lungs, where type II alveolar epithelial cells (AEC IIs) are subjected to persistent stretching and overactivated myofibroblasts experience malignant interactions during mechanotransduction, it becomes imperative to develop effective strategies to modulate the pulmonary mechanical microenvironment. Herein, cyclo (RGDfC) peptide‐decorated zeolitic imidazolate framework‐8 nanoparticles (named ZDFPR NPs) are constructed to target and repair the aberrant mechanical force levels in pathological lungs. Specifically, reduces mechanical tension in AEC IIs by pH‐responsive ZDFPR NPs that release zinc ions and 7, 8‐dihydroxyflavone to promote alveolar repair and differentiation. Meanwhile, malignant interactions between myofibroblast contractility and extracellular matrix stiffness during mechanotransduction are disrupted by the fasudil inhibition ROCK signaling pathway. The results show that ZDFPR NPs successfully restored pulmonary mechanical homeostasis and terminated the fibrosis process in bleomycin‐induced fibrotic mice. This study not only presents a promising strategy for modulating pulmonary mechanical microenvironment but also pioneers a novel avenue for IPF treatment.

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Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy

Li,

Lin,

Han

et al. 2024

Advanced Materials

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Sequential activation of osteogenic microenvironment via composite peptide-modified microfluidic microspheres for promoting bone regeneration

Wu,

Xu,

et al. 2025

Biomaterials

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Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

He,

Han,

Zhao

et al. 2024

Journal of Controlled Release

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Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine

Cited by 9 publications

References 243 publications

Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy

Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy

Sequential activation of osteogenic microenvironment via composite peptide-modified microfluidic microspheres for promoting bone regeneration

Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

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