Engineering a Cortisol Sensing Enteric Probiotic

Litteral, Vaughn; Migliozzi, Rebecca; Metzger, David; McPherson, Craig; Saldanha, Roland

doi:10.1021/acsbiomaterials.2c01300

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…( Cat Nos.17823-19829-18125-17684-17364-20149-18670) C reactive protein was measured in each serum specimen. (Thompson et al, 1999), Calcium (Tietz, 1995), Chloride (Molleman et al ., 2003), Uric acid (Lieberman et al, 2007), Albumin (Sugio et al, 1999 ), Total protein (Gutteridge, and Thornton, 2005), Using an ELISA kit purchased from Siemens healthcare diagnostic Company United kingdom, ( Cat Nos.180731-198321) , Cortisol (Litteral et al, 2023), Aldosterone (Palmer et al, 2000), Using an ELISA kit purchased from Siemens healthcare diagnostic Company United kingdom, (Cat Nos.180739-1764523)Anti-diuretic hormone (ADH) (Sukhovet al, 1993) and Parathyroid hormone (PTH) (Coetzee et al, 2004).…”

Section: Assay Methods 251 Biochemical Analysismentioning

confidence: 99%

Biochemical and Molecular Study of Lactuca sativa on Diuresis- induced experimentally in Rats.

Awadein,

Ali,

Muhammed Mahfouz

et al. 2024

Benha Veterinary Medical Journal

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This study investigated the biochemical and molecular effects of Lactuca sativa (lettuce) on diuresis induced experimentally in rats using furosemide. Diuresis, characterized by excessive urine production, is associated with various factors such as diet, diuretics, diabetes, and temperature. There were four groups of forty male rats (10 in each). Group I, or the normal control group, was given no medication. Group II, or the L. sativa group, rats received 2 Ml of a suspension of 150 mg/kg b.w of spray dried powder of L. sativa orally daily for 30 days. Group III (the furosemide group), rats received I/P injections of 0.4 ml of a dose of 40 mg/kg b.w./ of furosemide once daily for 30 days in order to induce diuresis. Group IV(L.sativa treated group) rats received 2 ml of a suspension of 150 mg/kg b.w of spray dried powder of L. sativa orally daily for 30 days Plus I/P injections of 0.4 Ml of a dose of 40 mg/kg b.w./ of furosemide once daily for 30 days. Results showed that furosemide induced significant changes in serum electrolyte levels, kidney function tests, and hormonal levels. However, L. sativa treatment in diuretic rats demonstrated a mitigating effect, normalizing several parameters. The gene expression of angiotensin-converting enzyme and Renin was downregulated in the L. sativa-treated group. In conclusion, L. sativa exhibited potential benefits in maintaining electrolyte balance and kidney function in diuretic-induced rats. These findings suggest a potential therapeutic role for L. sativa in conditions involving electrolyte imbalances and renal dysfunction, warranting further investigation, including clinical studies in human subjects.

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