Engineering a material-genetic interface as safety switch for embedded therapeutic cells

Jerez‐Longres, Carolina; Gómez-Matos, Marieta; Becker, Jan Ulrich; Hörner, Maximilian; Wieland, Franz-Georg; Timmer, Jens; Weber, Wilfried

doi:10.1016/j.bioadv.2023.213422

Cited by 5 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Weber and colleagues engineered a material-genetic interface as the safety switch for mammalian therapeutic cells, in which they achieved the control of cell survival by allowing the designer cells to sense whether they were embedded in the hydrogels using a GEMS-based receptor. 215 …”

Section: Engineering Of Synthetic Receptorsmentioning

confidence: 99%

Programmable synthetic receptors: the next-generation of cell and gene therapies

Teng,

Cui,

Zhou

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy require to be further addressed in order to realize their full potential. Synthetic receptors, a synthetic biology tool that can precisely control the function of therapeutic cells and genetic modules, have been rapidly developed and applied as a powerful solution. Delicately designed and engineered, they can be applied to finetune the therapeutic activities, i.e., to regulate production of dosed, bioactive payloads by sensing and processing user-defined signals or biomarkers. This review provides an overview of diverse synthetic receptor systems being used to reprogram therapeutic cells and their wide applications in biomedical research. With a special focus on four synthetic receptor systems at the forefront, including chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors, we address the generalized strategies to design, construct and improve synthetic receptors. Meanwhile, we also highlight the expanding landscape of therapeutic applications of the synthetic receptor systems as well as current challenges in their clinical translation.

show abstract

Section: Engineering Of Synthetic Receptorsmentioning

confidence: 99%

Programmable synthetic receptors: the next-generation of cell and gene therapies

Teng,

Cui,

Zhou

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials

Wang,

Hu,

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

At the intersection of synthetic biology and materials science, engineered living materials (ELMs) exhibit unprecedented potential. Possessing unique “living” attributes, ELMs represent a significant paradigm shift in material design, showcasing self‐organization, self‐repair, adaptability, and evolvability, surpassing conventional synthetic materials. This review focuses on reviewing the applications of ELMs derived from bacteria, fungi, and plants in environmental remediation, eco‐friendly architecture, and sustainable energy. The review provides a comprehensive overview of the latest research progress and emerging design strategies for ELMs in various application fields from the perspectives of synthetic biology and materials science. In addition, the review provides valuable references for the design of novel ELMs, extending the potential applications of future ELMs. The investigation into the synergistic application possibilities amongst different species of ELMs offers beneficial reference information for researchers and practitioners in this field. Finally, future trends and development challenges of synthetic biology for ELMs in the coming years are discussed in detail.This article is protected by copyright. All rights reserved

show abstract

Programmable living materials joint special issue editorial

Zhong,

Sankaran

2023

Biomaterials Advances

View full text Add to dashboard Cite

Engineering a material-genetic interface as safety switch for embedded therapeutic cells

Cited by 5 publications

References 48 publications

Programmable synthetic receptors: the next-generation of cell and gene therapies

Programmable synthetic receptors: the next-generation of cell and gene therapies

Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials

Programmable living materials joint special issue editorial

Contact Info

Product

Resources

About