Engineering and characterization of a hydrogel mimicking subcutaneous interstitial space

Rodler, Agnes; Samanta, Ayan; Goh, Wen-Jun; Hilborn, Jöns; Hansson, Per

doi:10.1016/j.eurpolymj.2023.112739

Cited by 5 publications

(1 citation statement)

References 73 publications

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“…One of the most commonly used stiffness measurement techniques for biomaterials or synthetic materials in biomedical research is shear rheometry. Based on shear stress or shear strain, rheological measurements can range from pascal to megapascal levels. − Mechanical characterization techniques and the associated measure(s) of stiffness commonly employed in matrix stiffness literature are presented (Table ).…”

Section: Extracellular Matrixmentioning

confidence: 99%

Exploiting Matrix Stiffness to Overcome Drug Resistance

Aydin,

Ozcelikkale,

Acar

2024

ACS Biomater. Sci. Eng.

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Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better treatment modalities. Given the matrix stiffness affecting the mechanotransduction capabilities of cancer cells, characterization of the related signal transduction pathways can provide a better understanding for developing novel therapeutic strategies. In this review, we aimed to summarize the recent advancements in tumor matrix biology in parallel to therapeutic approaches targeting matrix stiffness and its consequences in cellular processes in tumor progression and metastasis. The cellular processes governed by signal transduction pathways and their aberrant activation may result in activating the epithelial-tomesenchymal transition, cancer stemness, and autophagy, which can be attributed to drug resistance. Developing therapeutic strategies to target these cellular processes in cancer biology will offer novel therapeutic approaches to tailor better personalized treatment modalities for clinical studies.

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