Engineering caveolin-mediated endocytosis in Saccharomyces cerevisiae

Zhang, Qian; Li, Ning; Lyv, Yunbin; Yu, Shiqin; Zhou, Jingwen

doi:10.1016/j.synbio.2022.06.008

Cited by 3 publications

(1 citation statement)

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“…The main function of caveolae is to form membrane buds and endocytic vesicles. Zhang 30 utilized caveolae to successfully facilitate the endocytosis of soybean oil in Saccharomyces cerevisiae. Their findings suggested that caveolae can serve as an optimal transport system for hydrophobic substrates.…”

Section: Mid−long Chain Dicarboxylic Acids Derived From Alkanes and F...mentioning

confidence: 99%

Mid–Long Chain Dicarboxylic Acid Production via Systems Metabolic Engineering: Progress and Prospects

Gu,

Zhu,

Zhang

et al. 2024

J. Agric. Food Chem.

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Mid-to-long-chain dicarboxylic acids (DCA i , i ≥ 6) are organic compounds in which two carboxylic acid functional groups are present at the terminal position of the carbon chain. These acids find important applications as structural components and intermediates across various industrial sectors, including organic compound synthesis, food production, pharmaceutical development, and agricultural manufacturing. However, conventional petroleum-based DCA production methods cause environmental pollution, making sustainable development challenging. Hence, the demand for eco-friendly processes and renewable raw materials for DCA production is rising. Owing to advances in systems metabolic engineering, new tools from systems biology, synthetic biology, and evolutionary engineering can now be used for the sustainable production of energy-dense biofuels. Here, we explore systems metabolic engineering strategies for DCA synthesis in various chassis via the conversion of different raw materials into mid-to-long-chain DCAs. Subsequently, we discuss the future challenges in this field and propose synthetic biology approaches for the efficient production and successful commercialization of these acids.

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Section: Mid−long Chain Dicarboxylic Acids Derived From Alkanes and F...mentioning

confidence: 99%