Engineering Design Methodology for Bio-Mechatronic Products

Abstract

Four complex biotechnology products/product systems (a protein purification system, a bioreactor system, a surface plasmon resonance biosensor, and an enzymatic glucose analyzer) are analyzed using conceptual design principles. A design model well-known in mechanical system design, the Hubka-Eder (HE) model, is adapted to biotechnology products that exemplify combined technical systems of mechanical, electronic, and biological components, here referred to as biomechatronic systems. The analysis concludes that an extension of the previous HE model with a separate biological systems entity significantly contributes to facilitating the functional and systematic analyses of bio-mechatronic systems.

Scale‐up of cell culture bioreactors using biomechatronic design

“…Any biotechnology machine or apparatus or system can be designed with the support of the methodology, either it is a largescale process, a protein purification system, a biosensor or microarray instrument [18][19][20].…”

“…Biomechatronic design has recently been described for a variety of such complex biotechnology products [18][19][20][21][22]. Examples include bioreactors, biosensors, chromatographic protein purification systems [19,20], stem cell manufacturing plants and quality control for bio-production using to Process Analytical Technology (PAT) and Quality-by-Design methods [21,22].…”

“…Examples include bioreactors, biosensors, chromatographic protein purification systems [19,20], stem cell manufacturing plants and quality control for bio-production using to Process Analytical Technology (PAT) and Quality-by-Design methods [21,22].…”

“…These systems have in common that they all cause effects on the transformation process. For biotechnology products the biological systems have key roles in the transformation, but also their interactions with the other systems are crucial for efficient operation [19,20].…”

Conceptual Design of an Operator Training Simulator for a Bio-Ethanol Plant

“…In a number of concrete examples, it has been shown how the methodology can structure and improve the design work at the same time as the work is facilitated and speeded up. Examples where the methodology have been applied are the design of upstream and downstream equipment, biosensors, biochips, diagnostic devices and whole bioprocess systems [22][23][24]. So far, however, the methodology has not been applied in the designing of OTSs.…”