The latest COVID-19 pandemic is a specific and unusual event. It forced universities to close their doors and move fully to distance education. The sudden shift from traditional education to full distance education created many challenges and difficulties for universities, faculty members, and students. This study aims to investigate the challenges and obstacles faced by undergraduate women in Saudi Arabia universities while using online-only learning during the COVID-19 pandemic outbreak. Moreover, this study provides some recommendations to address these challenges from undergraduate women’s perspectives. The study used a qualitative research methodology to investigate the challenges and difficulties. The participants were undergraduate women selected using random purposive sampling technique from the population of College of Computer and Information Sciences (CCIS) at Princess Nourah Bint Abdulrahman University (PNU), Riyadh, Saudi Arabia. The final sample consisted of 68 undergraduate women who responded to a predesigned open-ended questionnaire that was sent via e-mail to targeted respondents. The data gathered from the questionnaire were analyzed using qualitative content analysis. Results of the research revealed that the most obvious challenges identified by the participants were technical issues, lack of in-person interaction, distractions and time management, lack of a systematic schedule, stress and psychological pressure, missing the traditional university environment, limited availability of digital devices, and lack of access to external learning resources.