Engineering elastic sealants based on gelatin and elastin‐like polypeptides for endovascular anastomosis

Abstract

Cerebrovascular ischemia from intracranial atherosclerosis remains difficult to treat. Although current revascularization procedures, including intraluminal stents and extracranial to intracranial bypass, have shown some benefit, they suffer from peri-and postoperative morbidity. To address these limitations, here we developed a novel approach that involves gluing of arteries and subsequent transmural anastomosis from the healthy donor into the ischemic recipient. This approach required an elastic vascular sealant with distinct This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Designing a Nitro-Induced Sutured Biomacromolecule to Engineer Electroconductive Adhesive Hydrogels

“…To demonstrate noncovalent interaction mediated dynamic molecular rearrangements, S-nCAGE 1 hydrogel, with the best mechanical properties (highest ultimate strength, stretchability, toughness, and tensile modulus), underwent cyclic compression test (Figure g), which exhibited an energy loss of ∼20% upon completion of 20 cycles (Figure h). This was comparable with the energy loss of an elastic hydrogel synthesized with elastin like polypeptide (30% energy loss after 10 cycles). Interestingly, the engineered S-nCAGE 1 hydrogel demonstrated lower energy loss as compared to an elastic sealant made of modified recombinant protein, methacryloyl-substituted tropoelastin (MeTro), which was optimized to seal elastic tissues (lungs and blood vessels) in vivo using small and large animal models.…”

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

“…Due to this highly cross-linked structure of elastin, tissues can undergo high deformation [ 91 , 174 , 175 ]. For these reasons, EL-based hydrogels have been posed as a prime biomaterial, with better mechanical properties than most biopolymeric hydrogels and good biocompatibility (>80%), although further research is required to optimize elastin-based hydrogels’ in vivo performance [ 92 , 94 , 95 ]. Unal et al (2021) developed a hybrid GelMA/elastin-based composite hydrogel that showed excellent biodegradation ability in vivo when implanted subcutaneously in a murine animal model, as well as remarkable biocompatibility and mechanical properties with potential for vascular applications, specifically for endovascular anastomosis [ 94 ].…”

Photocurable extracellular matrix sealant for cessation of venous hemorrhage

“…Bioadhesives and sealants can be classified based on their material makeup, adhesion mechanism, method for adhesion initiation, and biocompatibility. 8,30 Multiple biomedical sealants and hemostatic agents, including TISSEEL ® (fibrin sealant), 31 GelMA/GelMAC, 32,33 BioGlue, [34][35][36] and Gelfoam 37,38 all fit into the category of internal/intrabdominal bioadhesives and have shown clinical efficacy in stopping bleeds and initiating the woundhealing process, but every sealant has its limitations.…”