2022
DOI: 10.26434/chemrxiv-2022-snxxm
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Engineering enzyme substrate scope complementarity for promiscuous cascade synthesis

Abstract: Biocatalytic cascades are uniquely powerful for the efficient, asymmetric synthesis of bioactive compounds. The high specificity of enzymes can enable one-pot reactions where the substrates, intermediates, and products react only with the intended enzyme. However, this same specificity can hinder the substrate scope of biocatalytic cascades because each constituent enzyme requires complementary activity. Here, we implement a substrate multiplexed screening (SUMS) approach to improve the substrate scope overlap… Show more

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