Engineering Fe/Mn-doped zinc oxide nanosonosensitizers for ultrasound-activated and multiple ferroptosis-augmented nanodynamic tumor suppression

Hu, Zhongqian; Song, Xinran; Li, Ding; Cai, Yu; Yu, Luodan; Zhang, Lijuan; Zhou, Yajun; Chen, Yu

doi:10.1016/j.mtbio.2022.100452

Cited by 22 publications

(26 citation statements)

References 55 publications

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“…42,43 Two distinct Mn 2p peaks are observed at 641.1 and 653.1 eV, which could be assigned to Mn 2p 3/2 and 2p 1/2 peaks and suggest the existence of Mn(II) ions (Figure 2e,f). 2,31 We measured the magnetic properties of pretreated MnIONs and HMNs by a superconducting quantum It should be noted that the M s values show gradual decreasing trend with the increase of void ratio, which is independent of the dopant ratio. This phenomenon could be attributed to the hollow structure, disrupting the long-range order of magnetic spin, interrupting magnetic dipole coupling, and leading to a decrease in crystallinity.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…X-ray photoelectron spectroscopy (XPS) was performed to analyze the surface structures of pretreated MnIONs and HMNs (Figure c,d). The XPS peaks in Fe 2p locate at 710.5 and 724.4 eV, corresponding to Fe 2p 3/2 and 2p 1/2 peaks, respectively. , Two distinct Mn 2p peaks are observed at 641.1 and 653.1 eV, which could be assigned to Mn 2p 3/2 and 2p 1/2 peaks and suggest the existence of Mn(II) ions (Figure e,f). , We measured the magnetic properties of pretreated MnIONs and HMNs by a superconducting quantum interference device (SQUID) magnetometer at a magnetic field of 5 T at 300 K (Figure g,h). Field-dependent magnetization ( M–H ) curves of all samples are smooth at ambient temperature.…”

Section: Resultsmentioning

confidence: 99%

“…42,43 Two distinct Mn 2p peaks are observed at 641.1 and 653.1 eV, which could be assigned to Mn 2p 3/2 and 2p 1/2 peaks and suggest the existence of Mn(II) ions (Figure 2e,f). 2,31 We measured the magnetic properties of pretreated MnIONs and HMNs by a superconducting quantum interference device (SQUID) magnetometer at a magnetic field of 5 T at 300 K (Figure 2g,h). Field-dependent magnetization (M−H) curves of all samples are smooth at ambient temperature.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The faster the dephasing process, the higher the T 2 relaxation . Therefore, MNPs with anisotropic morphologies and proper magnetic behaviors have been investigated as potential T 2 CAs. , To achieve early and accurate diagnosis, many attempts have been made to improve the relaxation rates of MNPs through optimizing their crystal structures, , including dopants − and morphologies. , …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Hollow Structures on T₁ and T₂ Relaxivities and Their Application in Accurate Tumor Imaging

Zeng,

Huo,

Wang

et al. 2023

Chem. Mater.

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Great progress in precisely controlling the structures of magnetic nanoparticles has been made to investigate structure− relaxivity relationships in recent years. However, the investigation of the influence of hollow structures with unique interior structures on the relaxation rate of magnetic nanoparticles is rare. Herein, we obtained a series of hollow manganese-doped iron oxide nanoparticles (MnIONs) with different void and dopant ratios through a controllable etch process and systemically investigated the influence of hollow structures on the T 1 /T 2 relaxation rate. Due to the increased surface-to-volume (S/V) ratio, hollow MnIO nanoparticles (HMNs) show increased T 1 relaxivity compared to solid MnIONs. The T 1 relaxivities of HMNs with different void ratios are proportion to the number of exposed magnetic ions and electronic relaxation time value, which are determined by the S/V ratio and dopant level. More importantly, HMNs exhibit reduced saturated magnetization values with increased T 2 relaxivities compared to solid MnIONs. The elevated T 2 relaxivities of HMNs are attributed to the increased number of magnetic cores per unit volume and magnetic field inhomogeneity induced by hollow structures. These parameters are highly dependent on their void ratios, thus eventually determining their T 2 relaxivities. In vivo studies demonstrate that HMNs with relatively high T 1 or T 2 relaxivity show superior sensitivity in tumor detection to traditional T 1 or T 2 contrast agents. This work summarized the effects and mechanisms of hollow structures on the T 1 and T 2 relaxation rates of magnetic nanoparticles, providing examples in vivo for the design of excellent T 1 or T 2 contrast agents (CAs) for early cancer diagnosis.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…42,43 Two distinct Mn 2p peaks are observed at 641.1 and 653.1 eV, which could be assigned to Mn 2p 3/2 and 2p 1/2 peaks and suggest the existence of Mn(II) ions (Figure 2e,f). 2,31 We measured the magnetic properties of pretreated MnIONs and HMNs by a superconducting quantum interference device (SQUID) magnetometer at a magnetic field of 5 T at 300 K (Figure 2g,h). Field-dependent magnetization (M−H) curves of all samples are smooth at ambient temperature.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Hollow Structures on T₁ and T₂ Relaxivities and Their Application in Accurate Tumor Imaging

Zeng,

Huo,

Wang

et al. 2023

Chem. Mater.

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“…As two trace elements indispensable to human body, iron (Fe) and manganese (Mn) boast significant biological activities strongly associated with human homeostasis maintenance . Recently, various Fe–Mn hybrid nanomaterials integrating dual-element performance characteristics have shown great promises in tumor diagnosis and therapy, due to their biocompatibility, low-cost advantages, and catalytic and magnetic features. , For instance, the combination of MnO and Fe 3 O 4 effectively integrated their T 1 and T 2 contrast-enhancing abilities for dual-contrast magnetic resonance imaging (MRI) . Nevertheless, as yet, there are no reports of Fe–Mn hybrid nanomaterials with an ATP-consuming efficiency.…”

mentioning

confidence: 99%

Engineering Seed-like Fe–Mn Nanomedicine with Ultrasmall Structure and ATP-Responsive Function for Tumor Metabolic and Redox Subversion

Yao

et al. 2023

ACS Materials Lett.

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Since adenosine triphosphate (ATP) is an indispensable substance for tumor survival, intracellular ATP regulation has emerged as a cutting-edge antineoplastic strategy. Nevertheless, most ATP-responsive anticancer nanomedicines are established with DNA structure, coordinate polymer, and glucose oxidase as the core. Herein, in order to excavate the design possibilities of ATP-responsive nanoplatforms, an ultrasmall iron (Fe)-manganese (Mn) nanomedicine (<5 nm) was designed by a combination of bottom-up and topdown approaches, employing Fe-based reductant and Mn-based oxidant as raw materials. Due to the polyvalent Fe/Mn states, as-prepared nanomedicine was featured with ATP, hydrogen peroxide (H 2 O 2 ), and nicotinamide adenine dinucleotide phosphate (NADPH) reactivities to disrupt the metabolic and redox homeostasis of breast cancer and bone metastases sites. In addition, this nanomedicine was well-suited to offer dual-mode T 1 /T 2 magnetic resonance imaging (MRI) for tumor detection. Therefore, this work provides a novel attempt for the exploitation of ultrasmall ATP-responsive antineoplastic nanomedicine.

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Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

Fan,

Ran,

Wang

et al. 2024

Adv Funct Materials

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Bone implant biomaterials are among the most used materials for clinical application. Despite significant advances in biocompatibility and osteoconductivity, conventional biomaterials lack the ability to cope with the pathological microenvironment (inflammation, infection, residual tumors, etc.) during bone repair. Semiconductor implant materials have unique electrical, optical, ultrasound, and thermal response properties, which facilitate non‐invasively and controllably dynamic repair of pathological bone defects. In this review, the design and synthesis of a new generation of semiconductor‐driven bone implant materials are summarized, the mechanism of action of semiconductive biomaterials' functional interfaces and the dynamic repair process of bone tissues are discussed, and new strategies for the problems encountered during clinical osseointegration is provided. Finally, the review outlooks the future of functional semiconductive implants for bone defect repair.

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Engineering Fe/Mn-doped zinc oxide nanosonosensitizers for ultrasound-activated and multiple ferroptosis-augmented nanodynamic tumor suppression

Cited by 22 publications

References 55 publications

Effect of Hollow Structures on T₁ and T₂ Relaxivities and Their Application in Accurate Tumor Imaging

Effect of Hollow Structures on T₁ and T₂ Relaxivities and Their Application in Accurate Tumor Imaging

Engineering Seed-like Fe–Mn Nanomedicine with Ultrasmall Structure and ATP-Responsive Function for Tumor Metabolic and Redox Subversion

Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

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Engineering Fe/Mn-doped zinc oxide nanosonosensitizers for ultrasound-activated and multiple ferroptosis-augmented nanodynamic tumor suppression

Cited by 22 publications

References 55 publications

Effect of Hollow Structures on T1 and T2 Relaxivities and Their Application in Accurate Tumor Imaging

Effect of Hollow Structures on T1 and T2 Relaxivities and Their Application in Accurate Tumor Imaging

Engineering Seed-like Fe–Mn Nanomedicine with Ultrasmall Structure and ATP-Responsive Function for Tumor Metabolic and Redox Subversion

Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

Contact Info

Product

Resources

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Effect of Hollow Structures on T₁ and T₂ Relaxivities and Their Application in Accurate Tumor Imaging

Effect of Hollow Structures on T₁ and T₂ Relaxivities and Their Application in Accurate Tumor Imaging