Engineering filamentous bacteriophages for enhanced gold binding and metallization properties

Zirpel, Nuriye Korkmaz; Arslan, Taner; Lee, Hyeji

doi:10.1016/j.jcis.2015.05.006

Cited by 7 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This achievement led to research in phage display selection of material-binding peptides. Several peptide sequences with affinity to different materials (e.g., platinum, palladium, titanium, silicon, silver, gold, zinc sulfide, cadmium sulfide, graphite, calcite, indium phosphide, chlorine-doped polypyrrole (PPyCl), and carbon nanotubes) have been identified [78,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187].…”

Section: Virus-based Drug Discoverymentioning

confidence: 99%

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

2019

View full text Add to dashboard Cite

Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides and antibodies, as well as other biotechnologically relevant polypeptides (including protease inhibitors, minimizing proteins, and cell/organ targeting peptides). Additionally, their high stability, easily modifiable surface, and enormous diversity in shape and size, distinguish viruses from synthetic nanocarriers used for drug delivery. Indeed, several plant and bacterial viruses (e.g., phages) have been investigated and applied as drug carriers. The ability to remove the genetic material within the capsids of some plant viruses and phages produces empty viral-like particles that are replication-deficient and can be loaded with therapeutic agents. This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities.

show abstract

Section: Virus-based Drug Discoverymentioning

confidence: 99%

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

2019

View full text Add to dashboard Cite

show abstract

Bacteriophage as a Therapeutic Agent to Combat Bacterial Infection: A Journey from History to Application

Panwar

Aarthy

2020

Biocommunication of Phages

View full text Add to dashboard Cite

Deep Learning Analysis of Binding Behavior of Virus Displayed Peptides to AuNPs

Lee

et al. 2018

Practical Applications of Computational Biology and Bioinformatics, 12th International Conference

View full text Add to dashboard Cite

Filamentous fd viruses have been used as biotemplates to develop nano sized carriers for biomedical applications. Genetically modified fd viruses with enhanced gold binding properties have been previously obtained by displaying gold binding peptides on viral coat proteins. In order to generate a stable colloidal system of dispersed viruses decorated with AuNPs avoiding aggregation, the underlying binding mechanism of AuNP-peptide interaction should be explored. In this paper, we therefore propose a macro scale self-assembly experiment using 3D printed models of AuNP and the virus to extend our understanding of Au binding process. Moreover, we present our image analysis algorithm which combines image processing techniques and deep learning to automatically examine the coupling state of the particles.

show abstract

Engineering filamentous bacteriophages for enhanced gold binding and metallization properties

Cited by 7 publications

References 38 publications

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Bacteriophage as a Therapeutic Agent to Combat Bacterial Infection: A Journey from History to Application

Deep Learning Analysis of Binding Behavior of Virus Displayed Peptides to AuNPs

Contact Info

Product

Resources

About