Engineering hairy cellulose nanocrystals for chemotherapy drug capture

Synthesis of cellulose nanocrystals from spinach waste for insulin delivery: comparison to chitosan nanoparticles

“…Recently, it was reported that the capacity of HCNs (derived from wood pulp) to attach to positively charged medicines in human serum and their anionic nature make them ideal for chemotherapeutic drug capture. 11 Therefore, in this study, the production of such nanocrystals from decellularized spinach leaves (as a cellulose source) was attempted. To the best of our knowledge, there are no studies evaluating HCN synthesis from decellularized forms and studying them as a drug carrier.…”

“…12 HCNs can be cationic or anionic hairy CNCs that benefit from electrostatic and steric colloidal stability due to their highly positively/negatively charged functional groups. 11 This feature gives them a high capacity to deliver distinct drugs more stably in solution and makes them less likely to aggregate compared to other types of CNCs. Furthermore, HCNs are a novel class of nanocelluloses that have improved biocompatibility compared to synthetic nanomaterials.…”

Ion Exchange Biomaterials to Capture Daptomycin and Prevent Resistance Evolution in Off-Target Bacterial Populations

“…A similar trend has been reported for the Na + effect on the cation removal capacity of carboxylated adsorbents. 36,37 Figure 5d shows the IXB-mediated DAP removal percentage and capacity at varying Ca 2+ concentrations. The DAP removal capacity decreased more than 50% when the Ca 2+ concentration increased from 0 to 500 mM, possibly because the , respectively.…”

Mussel-Inspired Nanocellulose Coating for Selective Neodymium Recovery

“…So far, Nd has been removed using adsorbents, such as alginate gels, phosphorus sol–gel materials, nanotubes, porous carbon, vermiculite, , regolith-hosted clay, and biosorbent microalgae . We have recently engineered a bio-based adsorbent based on cellulose, the most abundant biopolymer on earth, named anionic hairy cellulose nanocrystals, i.e., cellulose nanoparticles attached to disordered dicarboxylated cellulose chains bearing a high content (∼5 mmol g –1 ) of carboxylate groups for high-concentration Nd , or drug removal. The formation of hairy cellulose nanocrystals and evidence of hair location on both ends have been discussed in the literature. − The hairs impart the anionic hairy cellulose nanocrystals with a high adsorption capacity for neodymium ions (Nd 3+ ) and partial selectivity against calcium ions (Ca 2+ ) and ferrous ions (Fe 2+ ); however, the Nd 3+ removal percentage remains exceedingly low at a low adsorbate: adsorbent ratio as a result of the colloidal stability of unsaturated nanoparticles.…”

“…8 So far, Nd has been removed using adsorbents, such as alginate gels, 9 phosphorus sol−gel materials, 10 nanotubes, 11 porous carbon, 12 vermiculite, 13,14 regolith-hosted clay, 15 and biosorbent microalgae. 16 We have recently engineered a bio-based adsorbent based on cellulose, the most abundant biopolymer on earth, named anionic hairy cellulose nanocrystals, i.e., cellulose nanoparticles attached to disordered dicarboxylated cellulose chains bearing a high content (∼5 mmol g groups for high-concentration Nd 17,18 or drug 19 removal. The formation of hairy cellulose nanocrystals and evidence of hair location on both ends have been discussed in the literature.…”