Engineering hollow mesoporous silica nanoparticles to increase cytotoxicity

Pérez-Garnés, Manuel; Gutiérrez-Salmerón, María Teresa; Morales, Victoria; Chocarro-Calvo, Ana; Sanz, R.; García-Jiménez, Custodia; García-Muñoz, Rafael A.

doi:10.1016/j.msec.2020.110935

Cited by 25 publications

(15 citation statements)

References 46 publications

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“…Some studies have also found that in different liver cancer cell lines, nanomaterials have high cytotoxicity, which can increase the amount of soluble FOLR1 secreted by tumor cells 18,19 . The increase of the size or density of hollow mesoporous silica will increase its cytotoxicity, which can cause nuclear fragmentation and irreversible cell damage 20 . Nanoparticles can also cause DNA damage and cytotoxicity and bioaccumulation in both embryos and fetuses 21 .…”

Section: Introductionmentioning

confidence: 99%

“…18,19 The increase of the size or density of hollow mesoporous silica will increase its cytotoxicity, which can cause nuclear fragmentation and irreversible cell damage. 20 Nanoparticles can also cause DNA damage and cytotoxicity and bioaccumulation in both embryos and fetuses. 21 The production of ROS is a necessary condition for autophagy and cytotoxicity mediated by nanoparticles.…”

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confidence: 99%

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Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Zhao

Zhang

et al. 2021

Environmental Toxicology

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Mesoporous silica is widely used because of its unique and excellent properties, especially it can be used as a drug carrier and gene carrier in the biomedical field. After the mesoporous silica is put into clinical use, it is more likely to be exposed in human body. Therefore, the effect of mesoporous silica on human body cannot be ignored. The injury of vascular endothelial cells is a prerequisite for the occurrence of many cardiovascular diseases. As a drug and gene carrier, mesoporous silica increases its contact with vascular endothelial cells, so its toxic effect on cardiovascular system cannot be ignored. In this study, amino (NH2) and carboxyl (COOH) were modified on mesoporous silica SBA‐15 by post‐grafting. The results showed that it still maintained the one‐dimensional hexagonal mesoporous structure of SBA‐15 and had typical mesoporous structure. Then human umbilical vein endothelial cells (HUVECs) were infected with SBA‐15, NH2‐SBA‐15, and COOH‐SBA‐15. The results showed that the functionalized mesoporous silica SBA‐15 had cytotoxicity to HUVECs and damaged the cell membrane, but compared with the unmodified mesoporous silica SBA‐15 the cytotoxicity of functionalized mesoporous silica SBA‐15 was lower and the toxicity of carboxyl modified group was the lowest. By comparing the cell inhibition rate and the expression level of lactate dehydrogenate and reactive oxygen species induced by the three materials, oxidative damage and cell membrane damage may be two mechanisms of cytotoxicity. Mesoporous silica SBA‐15 has an effect on cardiovascular system by inducing the high expression of nitric oxide, intercellular adhesive molecule‐1 and vascular cell adhesive molecule‐1 in HUVECs. In summary, our results show that mesoporous silica is toxic to vascular endothelial cells.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Zhao

Zhang

et al. 2021

Environmental Toxicology

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“…In particular, the size and shape of the whole nanoparticles and the size of the pores are two of the most relevant characteristics. It is well stablished that the size and shape of MSNs have an important impact on their interaction inside of living organisms [ 45 , 46 ]. In general, the optimal nanoparticles must be spherical and porous so they can be able to have a large store capacity and controlled delivery [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Kidney-Protector Lipidic Cilastatin Derivatives as Structure-Directing Agents for the Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery

Martínez-Erro

Navas

Romaní-Cubells

et al. 2021

IJMS

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Mesoporous silica nanomaterials have emerged as promising vehicles in controlled drug delivery systems due to their ability to selectively transport, protect, and release pharmaceuticals in a controlled and sustained manner. One drawback of these drug delivery systems is their preparation procedure that usually requires several steps including the removal of the structure-directing agent (surfactant) and the later loading of the drug into the porous structure. Herein, we describe the preparation of mesoporous silica nanoparticles, as drug delivery systems from structure-directing agents based on the kidney-protector drug cilastatin in a simple, fast, and one-step process. The concept of drug-structure-directing agent (DSDA) allows the use of lipidic derivatives of cilastatin to direct the successful formation of mesoporous silica nanoparticles (MSNs). The inherent pharmacological activity of the surfactant DSDA cilastatin-based template permits that the MSNs can be directly employed as drug delivery nanocarriers, without the need of extra steps. MSNs thus synthesized have shown good sphericity and remarkable textural properties. The size of the nanoparticles can be adjusted by simply selecting the stirring speed, time, and aging temperature during the synthesis procedure. Moreover, the release experiments performed on these materials afforded a slow and sustained drug release over several days, which illustrates the MSNs potential utility as drug delivery system for the cilastatin cargo kidney protector. While most nanotechnology strategies focused on combating the different illnesses this methodology emphasizes on reducing the kidney toxicity associated to cancer chemotherapy.

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“…The N 2 adsorption–desorption isotherms ( Figure 6 ) of the Fe 3 O 4 @MSNs after the extraction and calcination processes show typical type IV curves with capillary condensation steps at a relative pressure of 0.35−0.4, corroborating the presence of mesopores. The Fe 3 O 4 @MSNs exhibit a type H 3 hysteresis loop, which might be attributed to the effect of the internal cavities or hollows [ 12 , 61 , 62 ]. The pore size distribution was calculated by means of the non-local density functional theory (NLDFT) model, obtaining a wide pore distribution as a result of the contribution of the different pore and intra-void sizes of the NPs ( Table 1 ), with a main contribution around 3.0 nm.…”

Section: Resultsmentioning

confidence: 99%

Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide

et al. 2021

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Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe3O4@MSNs). Additionally, the drug loading capability and the release of tryptophan from the silica nanoparticles were examined, as well as the cytostaticity and cytotoxicity of the Fe3O4@MSNs in different colon cancer cell lines. The results indicate that Fe3O4@MSNs have great potential for drug loading and drug delivery into specific target cells, thereby overcoming the limitations associated with conventional drug formulations, which are unable to selectively reach the sites of interest.

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Engineering hollow mesoporous silica nanoparticles to increase cytotoxicity

Cited by 25 publications

References 46 publications

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Kidney-Protector Lipidic Cilastatin Derivatives as Structure-Directing Agents for the Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery

Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide

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