Engineering Intelligent Nanosystems for Enhanced Medical Imaging

Moolenbroek, Guido T. van; Patiño, Tania; Llop, Jordi; Sánchez, Samuel

doi:10.1002/aisy.202000087

Cited by 37 publications

(40 citation statements)

References 284 publications

(450 reference statements)

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“…Therefore, the unique advantages of each imaging platform and processing methods should be considered, as each imaging modality is better suited for different organ compositions and depth‐of‐focus inside the body. [ 374 ] The main challenge, regarding untethered micro/nanorobotic research, is the ability to distinguish the micro/nanorobot structure from their environment (background subtraction) with sufficient acquisition resolution to track each step of motion in a 3D environment. Due to the complexity of the data acquired, algorithms, instead of medical staff would be required to identify and follow the microrobot motion through the body.…”

Section: Medical Imagingmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Medical Imagingmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…Therefore, the clinical imaging tools‐based localization of m‐bot swarms may be affordable whereas the in vivo localization of individual micro and nanoscale robots for precise surgery is still challenging. [ 407 ]…”

Section: Discussionmentioning

confidence: 99%

Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

et al. 2020

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Micro‐/nanorobots (m‐bots) have attracted significant interest due to their suitability for applications in biomedical engineering and environmental remediation. Particularly, their applications in in vivo diagnosis and intervention have been the focus of extensive research in recent years with various clinical imaging techniques being applied for localization and tracking. The successful integration of well‐designed m‐bots with surface functionalization, remote actuation systems, and imaging techniques becomes the crucial step toward biomedical applications, especially for the in vivo uses. This review thus addresses four different aspects of biomedical m‐bots: design/fabrication, functionalization, actuation, and localization. The biomedical applications of the m‐bots in diagnosis, sensing, microsurgery, targeted drug/cell delivery, thrombus ablation, and wound healing are reviewed from these viewpoints. The developed biomedical m‐bot systems are comprehensively compared and evaluated based on their characteristics. The current challenges and the directions of future research in this field are summarized.

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“…[ 1 ] Micro and nanodevices showing such active and adjustable navigation have gained considerable attention, as the propulsion mechanisms are now better understood, and different sophisticated designs have been realized. This is leading to an increase in the number of potential applications, e.g., sensing and bio‐sensing, [ 2 ] biomedicine, [ 3,4 ] imaging, [ 1 ] cargo manipulation and delivery, [ 5 ] and environmental remediation. [ 6 ] The swimmer motion is essentially based on two main types of propulsion: self‐propulsion, by either phoretic motion or bubble propulsion, and nonautonomous propulsion, which requires an external source of energy/stimuli.…”

Section: Methodsmentioning

confidence: 99%

“…For example, Sanchez's group defines the intelligence of nanosystems as their response, e.g., active navigation, to external impulses or to endogenous stimuli. [ 1 ] Micro and nanodevices showing such active and adjustable navigation have gained considerable attention, as the propulsion mechanisms are now better understood, and different sophisticated designs have been realized. This is leading to an increase in the number of potential applications, e.g., sensing and bio‐sensing, [ 2 ] biomedicine, [ 3,4 ] imaging, [ 1 ] cargo manipulation and delivery, [ 5 ] and environmental remediation.…”

Section: Methodsmentioning

confidence: 99%

Autonomous Chemotactic Light‐Emitting Swimmers with Trajectories of Increasing Complexity

Pavel

Salinas

Perro

et al. 2020

Advanced Intelligent Systems

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Miniaturized autonomous swimmers have become more and more important in many areas of research due to various fields of use, ranging from biomedical to environmental tasks. Precise and predictable control of their trajectories is a key ingredient for increasing their application potential. This can be typically achieved by using external forces such as magnetic or electric fields. An interesting alternative is to use intrinsic features of the swimmers, which allow them to exhibit chemotaxis. Such a built‐in “intelligence” enables more complex trajectories, relying on mechanisms that can be considered very basic analogs of decision‐making processes. Herein, autonomous light‐emitting chemoelectronic swimmers are presented that are able to navigate along trajectories with increasing complexity. Their decision‐making capacities are characterized by recording the light emitted along their path by a fully integrated light‐emitting diode. Chemotaxis is found to be the main driving force behind their behavior, allowing envisioning such systems for solving complex maze patterns.

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Engineering Intelligent Nanosystems for Enhanced Medical Imaging

Cited by 37 publications

References 284 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

Autonomous Chemotactic Light‐Emitting Swimmers with Trajectories of Increasing Complexity

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