Engineering liposomes for drug delivery: progress and problems

Gregoriadis, Gregory

doi:10.1016/s0167-7799(00)89017-4

Cited by 570 publications

(323 citation statements)

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“…(Lasic, 1992). Twenty-five years after the discovery of their immunological properties, liposomes now appear a major candidate adjuvant*with a liposome-based vaccine (against hepatitis A) being licensed for use in humans (Kirby, 1990;Gregoriadis, 1995). Vaccines based on novasomes (R) (non-phospholipid liposomes formed from single-chain amphiphiles, with or without other lipids) have been licensed for the immunization of fowl against ND virus and avian reovirus (Gupta et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of the immunoenhancement potential of Newcastle disease vaccine formulated as a cationic liposome

et al. 2012

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This study evaluates the enhancement of immune response of birds to Newcastle disease (ND) vaccine encapsulated in 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)-based liposomes. The vesicles of the liposomal ND vaccine were physically characterized for shape, particle size and zeta potential. The results of the analyses showed that vesicles of the liposomal ND vaccine were spherical and tightly packed. The mean size distribution was below 100 nm. The mean zeta potential was 24 mV. Sixty experimental birds were then divided into an unvaccinated group, a liposomal ND vaccine group and a live La Sota † vaccine group. Both the liposomal ND vaccine and live La Sota † vaccine groups were vaccinated orally at 3 and 6 weeks of age. The mean antibody titres, total and differential white blood cell count, and blood chemistry, respectively, were assessed. Ten birds from each group were challenged by oral administration of 0.2 ml virulent Herts 33 strain at 9 weeks of age. The log 2 mean antibody titre induced by the liposomal ND vaccine after secondary immunization of the birds was 9.6090.95 while that of the live La Sota † vaccine was 6.0090.63. Nine of the 10 challenged birds in the unvaccinated group died while none died from the liposomal ND vaccine group or the live La Sota † vaccine group. After the boost vaccination, the chickens vaccinated with the liposomal ND vaccine had a higher mean antibody titre, indicating that encapsulating ND vaccine in DOTAP-based liposome induced significantly higher immunity than the live La Sota † vaccine.

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Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of the immunoenhancement potential of Newcastle disease vaccine formulated as a cationic liposome

et al. 2012

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“…Due to the targeted delivery of toxic anticancer drugs, its toxicity has been reduced greatly than delivery of free anticancer drugs. [32][33][34] Entrapment of anticancer drugs greatly increased its lifetime, decreased its degradation rate, increased deposition in the tumor cells, and decreased uptake to the normal cells. Liposome with passively targeted tumor cells can increase vascular permeability.…”

Section: Liposome In Cancer Therapymentioning

confidence: 99%

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Rafe

2017

AJP

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Widespread applications of liposome make it most interested carrier system of research and development than other available carrier systems. The lipids nanomedicine system was the first to make the concept of nanomedicine delivery into clinical approach that made them an established drug delivery system in present time for enormous success. In its application, liposome drug delivery usually targets directly to the tissue, which may contain target recognition molecules or not. This article is intended to give a brief overview of liposomal drug delivery system, its worldwide applications, and future perspective. Literature search results revealed applications of the liposome are in the immunology, vaccine and antigen, target delivery, delivery of insoluble or poorly drugs, delivery of nucleic acids, tumor therapy, and in combination therapy. At present, liposomal delivery is very popular in developed country, but we hope that, in future, the liposomal drug delivery system will revolutionize in all parts of the world to make the drug delivery system as perfect and effective as possible.

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“…Liposomes represent the oldest and the most explored nano-and micro systems for biological studies on model membranes and for medical applications, especially for drug formulations, because they eliminate or suppress organ-specific toxic side-effects of various drugs (Allen, 1997). Through their 46-year history, liposomes have been approved as suitable delivery systems for applications ranging from cosmetics and dermatology, anti-infection and anticancer therapy and diagnostics up to human as well as veterinary vaccines (Gregoriadis, 1995). Liposomes are classified in terms of number of bilayers enclosing the sequestered aqueous volume as follows: unilamellar, oligolamellar, and multilamellar.…”

Section: General Characterisation Of Liposomesmentioning

confidence: 99%