Engineering magnetically induced antibacterial organic/inorganic hybrid nanoparticles for the treatment of periodontitis

Mixed‐charge cellulose nanocrystal modified cellulose acetate membrane with endotoxin scavenging ability and antibacterial properties

“…Finally, the erythrocyte suspension incubated for 4 h was centrifuged again at 3500 rpm for 10 min, the supernatant was collected and its absorbance at 540 nm was measured with a microplate reader (Biotek synergy H1, Germany), and five independent parallel samples were set up for each group. The formula for calculating the hemolysis rate of the membrane is as follows 41 :…”

Recent advances in metal nanoparticles to treat periodontitis

“…Additionally, Hematoxylin and eosin (HE) staining supported the histological findings that the AMPs treatment group had increased alveolar ridge height and bone density but decreased inflammatory factor infiltration, supporting the therapeutic impact of AMPs on periodontitis. As a result, it is anticipated that the AMPs suggested in this research will be extensively used as drug carriers for the treatment of periodontitis [ 118 ]. In a different study, scientists added MNPs and the antibacterial compound dimethylaminododecyl methacrylate (DMADDM) to the EndoREZ root canal sealer.…”

“… AuNPs 45 nm AuNPs, anti-inflammatory effect, and improve periodontal inflammation By directly modulating hPDLCs and indirectly modulating macrophage phenotypes, AuNPs could create a microenvironment with limited inflammatory cytokine levels and reparative cytokines like BMP-2, thereby inducing PDLC differentiation, periodontal tissue regeneration, and the prevention of periodontitis progression In vivo and in vitro [ 70 ] AgNPs 1–100 nm, smaller particle size, higher surface area, and quantum confinement effects Using AgNPs as an alternative to topical antiseptics and antimicrobial agents, as well as in combination with other antimicrobial agents for a synergistic impact and local drug delivery during periodontal treatment, provides a window of opportunity for further study in the field. CHX and AgNPs are both potent antimicrobials that are effective against a wide range of periodontal and oral infections In vitro [ 55 ] ZnONPs Antimicrobial properties, the absorption peak of ZnNPs was in the range of 230–330 nm Individuals with chronic periodontitis have higher levels of ALT enzyme activity in their saliva compared to healthy controls, and ZnONPs have been shown to increase ALT enzyme activity in these individuals 20 patients with chronic periodontitis disease [ 98 ] MNPs Simple synthesis, intrinsic antimicrobial activity, low toxicity, and high versatility In vitro antibacterial investigations showed that antibacterial MNPs could eliminate bacterial biofilms using magnetic inductivity and the nanosize effect of NPs in conjunction with the antibacterial impact of PHMB, achieving a clearance rate of close to 80% In vivo and in vitro [ 118 ] NiNPs Cheap enough for intensive use, antibacterial activities, and safe, NPs obtained are smaller than 25 nm with low polydispersity All S. epidermidis clinical isolates were shown to be capable of biofilm generation in the investigation. The production of biofilm was shown to be suppressed by NiNPs.…”

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

“…This journal is © The Royal Society of Chemistry 2023 ments. 172 PHMB was deposited on the surface of the nanoparticles through electrostatic interaction, which could effectively enter the periodontal pocket directly to eliminate periodontal plaque and inactivate target bacteria.…”

“…Guo et al engineered antibacterial magnetic nanoparticles (Fe 3 O 4 @SiO 2 @SA) that were capable of anchoring PHMB via magnetic induction-targeted fixation for periodontitis treatments. 172 PHMB was deposited on the surface of the nanoparticles through electrostatic interaction, which could effectively enter the periodontal pocket directly to eliminate periodontal plaque and inactivate target bacteria.…”