Engineering Molybdenum‐Assisted Tellurium Nanosonosensitizers for Enhanced Sonodynamic Tumor Nanotherapy

Abstract

Materdicine-augmented sonodynamic therapy has emerged as an efficient noninvasive strategy for cancer treatment by generating reactive oxygen species associated with the cavitation effect and sonosensitizers. However, semiconductor-based inorganic nanosonosensitizers have undesirable nondegradability, which can cause unsatisfactory therapeutic efficacy and potential toxicity. With the aim of overcoming this obstacle, in this study, Mo-assisted Te (MT) nanosonosensitizers with high oxidative degradation abilities are engineered for photoacoustic imaging (PA)-guided sonodynamic tumor nanotherapy. Intriguingly, the engineered MT nanosonosensitizers can generate abundant singlet oxygen under ultrasound irradiation to eradicate tumor cells, thereby demonstrating its ability to achieve high tumor growth inhibition rates. In particular, MT nanosonosensitizers exhibit oxidative degradation properties that guarantee desirable biocompatibility and potentiate clinical translation. Therefore, this study validates a paradigm for theoryoriented design of sonodynamic tumor nanotherapy.

Recent Advances and Mechanism of Nanomaterials Promoting Tumor Metastasis

“…24,25 New therapies based on the special properties of nanomaterials have also emerged, such as photothermal and photodynamic therapies as well as magnetic nanoparticle hyperthermia. 26 Nanomaterials can also act as drug carriers or additives to enhance the effect of tumor treatment, such as liposomal drug delivery, radiotherapy sensitization, radiofrequency ablation (RFA), etc. 27−29 The role of some nonmetallic nanomaterials in tumor treatment has also been gradually discovered, such as C 60 , carbon nanotubes (CNTs), graphene, chitosan nanoparticles, etc., which shows great potential in the field of tumor therapy.…”

“…Nanomaterials have good biocompatibility and unique optical, thermodynamic, magnetic, and mechanical properties. , First of all, nanomaterials can be directly applied to tumor therapy as drugs. Due to their own antigenicity and cytotoxicity, some nanomaterials can kill tumor cells with the help of the immune system or directly. , New therapies based on the special properties of nanomaterials have also emerged, such as photothermal and photodynamic therapies as well as magnetic nanoparticle hyperthermia . Nanomaterials can also act as drug carriers or additives to enhance the effect of tumor treatment, such as liposomal drug delivery, radiotherapy sensitization, radiofrequency ablation (RFA), etc. − The role of some nonmetallic nanomaterials in tumor treatment has also been gradually discovered, such as C 60 , carbon nanotubes (CNTs), graphene, chitosan nanoparticles, etc., which shows great potential in the field of tumor therapy .…”

Platinum nanoparticle-anchored metal–organic complex nanospheres by a coordination–crystallization approach for enhanced sonodynamic therapy of tumors

“…[4][5][6][7] Recently, different sonosensitizers have been developed to enhance the therapeutic efficacy of SDT via mediating the generation efficiency of ROS. [8][9][10][11] Metal-organic complexes (MOCs) formed by the coordination of metal-ions or clusters with organic ligands have significant potential for SDT applications due to their unique sound responsiveness and rapid diffusion of ROS. [12][13][14][15][16][17][18][19] In addition, noble metal nanoparticles (NMNPs) have attracted great interest in SDT because of their special intrinsic properties, such as enzyme-like activity, which can enhance the generation of ROS.…”

Catalase-like pleated niobium carbide MXene loaded with polythiophene for oxygenated sonodynamic therapy in solid tumor

“…1–3 Sonodynamic therapy (SDT) is a novel non-invasive therapeutic technique that has excellent deep tissue penetration capability; thus, it can potentially be used for treating deep solid tumors. 4,5 In SDT, the sonosensitizer generates reactive oxygen species (ROS) to kill cancer cells under ultrasound (US) irradiation. 6,7 In general, inorganic sonosensitizers, including TiO 2 nanoparticles (NPs) and their oxygen-deficient NPs, carbon NPs, and silicon NPs, suffer from a long biometabolic cycle and have poor biocompatibility, which limit their clinical translation and application.…”