Engineering nanoenzymes integrating Iron-based metal organic frameworks with Pt nanoparticles for enhanced Photodynamic-Ferroptosis therapy

Ye, Yuyun; Yu, Hongli; Chen, Bohan; Zhao, Yifan; Lv, Bai; Xue, Guanghe; Sun, Yong; Cao, Jie

doi:10.1016/j.jcis.2023.05.003

Cited by 19 publications

(7 citation statements)

References 44 publications

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“…Cao et al reported the development of a nanozyme (HMPC) loaded with Pt NPs on an iron-based MOF, which not only generated Fe 2+ and • OH through the Fenton reaction to deplete GSH but also decomposed H 2 O 2 to produce O 2 via the CAT-like activity of Pt. 215 As a result, HMPC exhibited enhanced PDT efficacy. Furthermore, nanozymes can exploit the properties of GSH-OXD to consume GSH for boosting PDT.…”

Section: Chemodynamic Therapymentioning

confidence: 99%

“…Despite significant advancements in the development of nanozymes with CAT-like activity for enhanced PDT, there remains a substantial opportunity to enhance their efficacy considering the potent scavenging effect of GSH within the TME. Cao et al reported the development of a nanozyme (HMPC) loaded with Pt NPs on an iron-based MOF, which not only generated Fe 2+ and • OH through the Fenton reaction to deplete GSH but also decomposed H 2 O 2 to produce O 2 via the CAT-like activity of Pt . As a result, HMPC exhibited enhanced PDT efficacy.…”

Section: Application Of Nanozymes In Enhancing Anticancer Effectsmentioning

confidence: 99%

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as promising therapeutic nanodrugs that provide a reference for cancer therapy. In this review, we present recent breakthrough nanozymes for cancer treatment. First, we comprehensively outline the preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal method, chemical reduction method, biomimetic mineralization method, and sol−gel method. Subsequently, we elucidate the catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like activities), oxidase (OXD)-like activities) and superoxide dismutase (SOD)-like activities) of transition-metal-based nanozymes along with their activity regulation strategies such as morphology control, size manipulation, modulation, composition adjustment and surface modification under environmental stimulation. Furthermore, we elaborate on the diverse applications of transition-metal-based nanozymes in anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), immunotherapy, and synergistic therapy. Finally, the challenges faced by transition-metal-based nanozymes are discussed alongside future research directions. The purpose of this review is to offer scientific guidance that will enhance the clinical applications of nanozymes based on transition metals.

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Section: Chemodynamic Therapymentioning

confidence: 99%

Section: Application Of Nanozymes In Enhancing Anticancer Effectsmentioning

confidence: 99%

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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“…200,201 Ligand modification solves the problems of being removed from the blood circulation and poor tumor localization effect by modifying small targeting ligands or biomimetic cell membranes. 202,203 The intelligent response nanosystem achieves temporal and spatial control through external stimuli such as radiation, light, ultrasound, magnetic field (MF), and internal stimuli such as ROS, GSH, pH, and glucose. Some of these stimuli not only control drug release and improve drug enrichment but also enhance the efficacy of ferroptosis treatment through synergistic treatment.…”

Section: Nanoparticles Combination Therapy Based On Ferroptosis and O...mentioning

confidence: 99%

The application of nanoparticles based on ferroptosis in cancer therapy

Li,

Wei,

Yan

et al. 2024

J. Mater. Chem. B

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“…The MOFs containing photosensitizers can convert oxygen from tumour tissues into monoclinic oxygen. 125 The MOFs not only act as delivery carriers for photosensitizers to improve water solubility, but also act as inducers of ferroptosis, which converts O 2 from tumour tissues into monoclinic O 2 .…”

Section: Synergistic Therapies Involving Nanozymes In Cancer Treatmentmentioning

confidence: 99%

Nanozyme-enhanced ferroptosis for cancer treatment

Ming,

Huang,

Huang

et al. 2024

Mater. Chem. Front.

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Engineering nanoenzymes integrating Iron-based metal organic frameworks with Pt nanoparticles for enhanced Photodynamic-Ferroptosis therapy

Cited by 19 publications

References 44 publications

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

The application of nanoparticles based on ferroptosis in cancer therapy

Nanozyme-enhanced ferroptosis for cancer treatment

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