Engineering nanoparticle communication in living systems by stigmergy: An application to enhance antitumor therapy in triple-negative breast cancer

Chitosan-g-estrone Nanoparticles of Palbociclib Vanished Hypoxic Breast Tumor after Targeted Delivery: Development and Ultrasound/Photoacoustic Imaging

“…The study demonstrated that MUC1 functionalized NPs selectively bind to the breast tumor. Hence, NPs conjugated with the targeting moiety can deliver the loaded drug to the targeted site for therapeutic applications …”

“…Hence, NPs conjugated with the targeting moiety can deliver the loaded drug to the targeted site for therapeutic applications. 75…”

Strategies for senolytic drug discovery

“…Heat shock proteins (HSPs) play key roles in promoting correct protein folding, assembly, and function. Expression of HSPs rapidly increases in response to stress conditions, driving cell survival in-part by heightened levels of anti-apoptotic factors such as Bcl-2 (Dubrez et al, 2020;Yenari et al, 2005). A screen of 97 autophagy modulators identified 17-DMAG and seven other HSP90 inhibitors as senolytics, suggesting HSP90 as a key senolytic target.…”

Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

“…20 MSNs are biocompatible and biodegradable 21,22 materials with a porous structure, large specific surface area and volume, chemically and thermally stable, and can be equipped with molecular gates (also known as gatekeepers or nanovalves) able to regulate cargo delivery in response to predefined physical, chemical, or biochemical stimuli. 23−27 Thanks to their advantageous properties, MSNs have become one of the most important platforms for drugcontrolled release 28,29 and they have been used in many biomedical applications, such as drug, 30,31 gene, 32,33 and RNA 34,35 delivery; bioimaging; 36,37 chemical communication; 38,39 stigmergy; 40,41 nanomotors; 42,43 biosensing; 44,45 and theragnostic 46 and tissue engineering. 47,48 MSNs can be functionalized not only with molecular gates but also with other organic ligands and inorganic nanoparticles to provide them versatile chemical and physical properties, 49,50 which made them extraordinary versatile nanoplatforms.…”

“…Thus, the delivery in cells remains the most significant hurdle in using miRNAs as therapeutic agents. , In this scenario, nanoparticles are potential tools for miRNA pharmacokinetics improvement, since they can avoid miRNA degradation, can ensure their delivery to the cytosol, accumulate in tumors thanks to the enhanced permeability and retention (EPR) effect, and could additionally be functionalized to target specific cells. , In particular, mesoporous silica nanoparticles (MSNs) are suitable candidates as miRNA delivery vectors . MSNs are biocompatible and biodegradable , materials with a porous structure, large specific surface area and volume, chemically and thermally stable, and can be equipped with molecular gates (also known as gatekeepers or nanovalves) able to regulate cargo delivery in response to predefined physical, chemical, or biochemical stimuli. − Thanks to their advantageous properties, MSNs have become one of the most important platforms for drug-controlled release , and they have been used in many biomedical applications, such as drug, , gene, , and RNA , delivery; bioimaging; , chemical communication; , stigmergy; , nanomotors; , biosensing; , and theragnostic and tissue engineering. , MSNs can be functionalized not only with molecular gates but also with other organic ligands and inorganic nanoparticles to provide them versatile chemical and physical properties, , which made them extraordinary versatile nanoplatforms.…”