Engineering of a GSH activatable photosensitizer for enhanced photodynamic therapy through disrupting redox homeostasis

Fu, Dong-ming; Wang, Qianqian; Kh, Lin; Huang, Ling; Xu, Jianhua; Wu, Haimei

doi:10.1039/d3ra04074g

RSC Adv.

2023

DOI: 10.1039/d3ra04074g

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Engineering of a GSH activatable photosensitizer for enhanced photodynamic therapy through disrupting redox homeostasis

Dong-ming Fu¹,

Qianqian Wang²,

Lin Kh³

et al.

Abstract: The novel NIR photosensitizer, CyI-S-diCF3, with excellent GSH consumption ability and 1O2 production efficiency, was successfully used for GSH depletion-assisted enhanced photodynamic therapy through disrupting redox homeostasis.

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2024

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Cited by 2 publications

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Glutathione‐responsive Aggregation‐induced Emission Photosensitizers for Enhanced Photodynamic Therapy of Lung Cancer

Sun,

Chen,

Lam

et al. 2024

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Lung cancer, a highly prevalent and lethal form of cancer, is often associated with oxidative stress. Photodynamic therapy (PDT) has emerged as a promising alternative therapeutic tool in cancer treatments, but its efficacy is closely correlated to the photosensitizers generating reactive oxygen species (ROS) and the antioxidant capacity of tumor cells. In particular, glutathione (GSH) can reduce the ROS and thus compromise PDT efficacy. In this study, a GSH‐responsive near‐infrared photosensitizer (TBPPN) based on aggregation‐induced emission for real‐time monitoring of GSH levels and enhanced PDT for lung cancer treatment is developed. The strategic design of TBPPN, consisting of a donor–acceptor structure and incorporation of dinitrobenzene, enables dual functionality by not only the fluorescence being activated by GSH but also depleting GSH to enhance the cytotoxic effect of PDT. TBPPN demonstrates synergistic PDT efficacy in vitro against A549 lung cancer cells by specifically targeting different cellular compartments and depleting intracellular GSH. In vivo studies further confirm that TBPPN can effectively inhibit tumor growth in a mouse model with lung cancer, highlighting its potential as an integrated agent for the diagnosis and treatment of lung cancer. This approach enhances the effectiveness of PDT for lung cancer and deserves further exploration of its potential for clinical application.

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Glutathione‐responsive Aggregation‐induced Emission Photosensitizers for Enhanced Photodynamic Therapy of Lung Cancer

Sun,

Chen,

Lam

et al. 2024

Small

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pH-Responsive self-assembled polymer-photosensitizer conjugate for activable photodynamic therapy

Banerjee,

Dan,

Ghosh

2024

Nanoscale

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Engineering of a GSH activatable photosensitizer for enhanced photodynamic therapy through disrupting redox homeostasis

Abstract: The novel NIR photosensitizer, CyI-S-diCF3, with excellent GSH consumption ability and 1O2 production efficiency, was successfully used for GSH depletion-assisted enhanced photodynamic therapy through disrupting redox homeostasis.

Cited by 2 publications

References 46 publications

Glutathione‐responsive Aggregation‐induced Emission Photosensitizers for Enhanced Photodynamic Therapy of Lung Cancer

Glutathione‐responsive Aggregation‐induced Emission Photosensitizers for Enhanced Photodynamic Therapy of Lung Cancer

pH-Responsive self-assembled polymer-photosensitizer conjugate for activable photodynamic therapy

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