Engineering of a universal polymeric nanoparticle platform to optimize the PEG density for photodynamic therapy

Yang, Xiaodong; Li, Jie; Yu, Yue; Wang, Junxia; Li, Dongdong; Cao, Ziyang; Yang, Xianzhu

doi:10.1007/s11426-019-9505-y

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…PEG has shown promising application due to several properties, namely, inertness in biological systems combined with the non-activation of immune components and low adsorption of biomolecules, such as proteins providing a prolonged circulation in the blood [30,76]. The importance of PEG in PDT was investigated by Yang and collaborators [77] using Ce6 as a photosensitizer, a PDT light source based on a 660 nm laser and synthetized polymers Polyethylene glycol (PEG) has gained attention due to its stealth behavior [72]. PEG has shown promising application due to several properties, namely, inertness in biological systems combined with the non-activation of immune components and low adsorption of biomolecules, such as proteins providing a prolonged circulation in the blood [30,76].…”

Section: Polymeric Npsmentioning

confidence: 99%

“…PEG has shown promising application due to several properties, namely, inertness in biological systems combined with the non-activation of immune components and low adsorption of biomolecules, such as proteins providing a prolonged circulation in the blood [30,76]. The importance of PEG in PDT was investigated by Yang and collaborators [77] using Ce6 as a photosensitizer, a PDT light source based on a 660 nm laser and synthetized polymers with different densities. It was demonstrated that the drug was detected in the circulation for a prolonged time and a higher amount of Ce6 was detected with high-density PEG nanoparticles.…”

Section: Polymeric Npsmentioning

confidence: 99%

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Nanoparticle Systems for Cancer Phototherapy: An Overview

et al. 2021

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Photodynamic therapy (PDT) and photothermal therapy (PTT) are photo-mediated treatments with different mechanisms of action that can be addressed for cancer treatment. Both phototherapies are highly successful and barely or non-invasive types of treatment that have gained attention in the past few years. The death of cancer cells because of the application of these therapies is caused by the formation of reactive oxygen species, that leads to oxidative stress for the case of photodynamic therapy and the generation of heat for the case of photothermal therapies. The advancement of nanotechnology allowed significant benefit to these therapies using nanoparticles, allowing both tuning of the process and an increase of effectiveness. The encapsulation of drugs, development of the most different organic and inorganic nanoparticles as well as the possibility of surfaces’ functionalization are some strategies used to combine phototherapy and nanotechnology, with the aim of an effective treatment with minimal side effects. This article presents an overview on the use of nanostructures in association with phototherapy, in the view of cancer treatment.

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Section: Polymeric Npsmentioning

confidence: 99%

“…PEG has shown promising application due to several properties, namely, inertness in biological systems combined with the non-activation of immune components and low adsorption of biomolecules, such as proteins providing a prolonged circulation in the blood [30,76]. The importance of PEG in PDT was investigated by Yang and collaborators [77] using Ce6 as a photosensitizer, a PDT light source based on a 660 nm laser and synthetized polymers with different densities. It was demonstrated that the drug was detected in the circulation for a prolonged time and a higher amount of Ce6 was detected with high-density PEG nanoparticles.…”

Section: Polymeric Npsmentioning

confidence: 99%

Nanoparticle Systems for Cancer Phototherapy: An Overview

et al. 2021

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“…PDT causes negligible drug resistance and has highly specific spatiotemporal selectivity. [ 6 ] Importantly, PDT, as an efficient ICD inducer, can initiate the immune response process to enhance tumor immunogenicity and is a promising method to maximize immunotherapeutic outcome. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Tumor Cell‐Responsive Photodynamic Immunoagent for Immunogenicity‐Enhanced Orthotopic and Remote Tumor Therapy

Chen

Xiong

Zhao

et al. 2022

Adv Healthcare Materials

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Combining photodynamic therapy (PDT) and immune checkpoint blockades is an efficient method to maximize immunotherapeutic outcome by boosting tumor immunogenicity and modulating the immunosuppressive tumor microenvironment. However, the always‐on bioactivity of photosensitizers or immune checkpoint inhibitors leads to uncontrollable side effects, limiting the in vivo therapeutic efficacy of treatments. An activatable strategy is of great importance for improving the selectivity during cancer therapy. In this study, a photodynamic immunomodulator, ICy‐NLG, is developed by conjugating the photosensitizer ICy‐NH2 with the indoleamine 2,3‐dioxygenase 1 inhibitor NLG919 through a glutathione (GSH)‐cleavable linker to achieve activatable photodynamic immunotherapy. The conjugation considerably suppresses both the PDT effect and the activity of the inhibitor. After ICy‐NLG is activated by high levels of GSH in tumor cells, the PDT effect is restored and leads to immunogenic tumor cell death. The released tumor‐associated antigens in conjunction with the activated immune checkpoint inhibitor induce a synergistic antitumor immune response, resulting in the growth inhibition of primary and distant tumors and the prevention of lung metastasis in mouse xenograft models.

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“…In spite of great progress in medicine, it is always difficult to treat cancer in clinic . Recently, nanomedicine- and nanotechnology-based strategies have been explored and developed for tumor treatment, such as light-triggered photothermal/photodynamic therapy (PTT/PDT), − nanocarrier-based chemotherapy, − and O 2 -dependent radiotherapy, , which have shown remarkable anticancer efficacy. Despite the substantial progress in nanotechnology-mediated tumor therapy, the defects including limited tissues penetration, premature drug leakage, multidrug resistance, and insufficient oxygen supply of solid tumor, especially nonspecificity, which results in undesirable side effects and damages to normal cells, greatly confine their clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Metal–Organic Framework-Integrated Enzymes as Bioreactor for Enhanced Therapy against Solid Tumor via a Cascade Catalytic Reaction

Bai

Peng

Guo

et al. 2019

ACS Biomater. Sci. Eng.

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Emerging natural-enzyme-based nanocatalytic tumor therapy depending on the high catalytic performance of natural enzymes has inspired great research interest in clinical applications. Nevertheless, the natural-enzyme-based catalytic therapy efficiency is seriously hampered by the low operational stability, poor delivery efficiency, and the short lifetime of enzymes. Herein, a bioreactor based on zeolitic imidazolate framework-8 (ZIF-8) was fabricated through one-pot embedding horseradish peroxidase (HRP) and glucose oxidase (Gox) strategy (ZIF-8@Gox/HRP) for synergistic cancer therapy. Notably, the obtained ZIF-8@Gox/HRP can efficiently consume endogenous glucose to generate gluconic acid and H2O2 for starving tumors, and subsequently, H2O2 was decomposed by encapsulated HRP to release high-toxic •OH radicals, inducing cancer cell apoptosis for oxidation therapy. Importantly, in vivo results showed that ZIF-8@Gox/HRP had an impressive tumor-suppression rate based on cascade catalytic reaction. Therefore, this work paves a new avenue to design smart enzyme-based platforms for safe and efficient cancer therapy.

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Engineering of a universal polymeric nanoparticle platform to optimize the PEG density for photodynamic therapy

Cited by 13 publications

References 32 publications

Nanoparticle Systems for Cancer Phototherapy: An Overview

Nanoparticle Systems for Cancer Phototherapy: An Overview

Tumor Cell‐Responsive Photodynamic Immunoagent for Immunogenicity‐Enhanced Orthotopic and Remote Tumor Therapy

Metal–Organic Framework-Integrated Enzymes as Bioreactor for Enhanced Therapy against Solid Tumor via a Cascade Catalytic Reaction

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