Engineering of bacterial toxins for research and medicine

Barbier, Julien; Gillet, Daniel

doi:10.1016/b978-0-12-800188-2.00035-5

Cited by 2 publications

(2 citation statements)

References 221 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The delivery of proteins, peptides, and oligonucleotides to cells is severely limited by their inability to permeate the cell membrane [ 103 ] and pore-forming toxins may provide a platform for drug delivery on a cellular level. This could open a new field for pharmaceutical nano-particle based treatments [ 102 , 104 ]. The ability of pore-forming toxins to deliver cargo directly to the cytoplasm has already been demonstrated using disarmed anthrax toxin and streptolysin O [ 103 , 104 , 105 , 106 , 107 ].…”

Section: Pharmaceutical and Biotechnological Applicationsmentioning

confidence: 99%

“…This could open a new field for pharmaceutical nano-particle based treatments [ 102 , 104 ]. The ability of pore-forming toxins to deliver cargo directly to the cytoplasm has already been demonstrated using disarmed anthrax toxin and streptolysin O [ 103 , 104 , 105 , 106 , 107 ]. A technique called suicide gene therapy could eventually employ pore forming toxins to deliver apoptotic agents directly into cancer cells [ 102 ].…”

Section: Pharmaceutical and Biotechnological Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods

et al. 2018

View full text Add to dashboard Cite

A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims to summarize what is known about bioactive compounds isolated from species of neglected marine gastropods, especially in the Turridae, Terebridae, Babyloniidae, Muricidae, Buccinidae, Colubrariidae, Nassariidae, Cassidae, and Ranellidae families. Multiple species have been reported to contain bioactive compounds with potential toxic activity, but most of these compounds have not been characterized or even clearly identified. The bioactive properties and potential applications of echotoxins and related porins from the Ranellidae family are discussed in more detail. Finally, the review concludes with a call for research on understudied species.

show abstract