Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors

Ramasamy, Thiruganesh; Ruttala, Hima Bindu; Chitrapriya, Nataraj; Poudal, Bijay Kumar; Choi, Jae Young; Kim, Ssang Tae; Youn, Yu Seok; Ku, Sae Kwang; Choi, Han‐Gon; Yong, Chul Soon; Kim, Jong Oh

doi:10.1016/j.actbio.2016.10.034

Cited by 113 publications

(57 citation statements)

References 46 publications

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“…43 Biodistribution of quercetin is low and interdisciplinary approaches have helped in improving the delivery of quercetin to the target tissues/cells. 46 Smartly designed pH-sensitive nanovehicles had precisely tailored drugto-carrier ratios that facilitated release of the drug in a controlled manner. 44 Dextran-aldehyde-quercetin conjugates were noted to be superior in efficacy as compared with nonconjugated quercetin.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Farooqı

Jabeen

Attar

et al. 2018

J of Cellular Biochemistry

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Recent technological and analytical breakthroughs in genomics and proteomics have deepened our understanding related to the multifaceted nature of cancer. Because of therapeutically challenging nature of cancer, there has been a renewed interest in phytochemistry, and much attention is currently being given to the identification of signaling pathway inhibitors. Data obtained through high-throughput technologies has provided a broader landscape of wiring maps of complex oncogenic signaling networks, thus revealing novel therapeutic opportunities. Increasingly, it is being realized that although our knowledge related to physiological and pathophysiological roles of signal transduction cascades has evolved rapidly, the clinical development of signaling pathway inhibitors has been challenging. Quercetin has attracted considerable attention because of its amazingly high pharmacological value. Research over decades has sequentially shown that quercetin effectively inhibited cancer development and progression. In this review, we have attempted to set the spotlight on the regulation of different cell signaling pathways by quercetin. We partition this multicomponent review into how quercetin effectively regulates the Wnt/β-catenin pathway, Janus kinase-signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers. We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin. MicroRNAs (miRNAs) have also emerged as versatile regulators of cancer, and contemporary studies have shed light on the ability of quercetin to control different miRNAs in various cancers. We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.

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Section: Preclinical Studiesmentioning

confidence: 99%

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Farooqı

Jabeen

Attar

et al. 2018

J of Cellular Biochemistry

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“…Ramasamy et al [31] reported a method for co-loading of DOX and quercetin (QUR) using a polypeptide nanoconstruct of the poly(phenylalanine)-b-poly(L-histidine)-b-poly(ethylene glycol) type. The smart pH-sensitive nanovehicle was used for synergistic endolysmosal delivery of DOX/QUR in cancer chemotherapy.…”

Section: Ph-responsive Micellesmentioning

confidence: 99%

Micelles Formed by Polypeptide Containing Polymers Synthesized Via N-Carboxy Anhydrides and Their Application for Cancer Treatment

et al. 2017

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Abstract:The development of multifunctional polymeric materials for biological applications is mainly guided by the goal of achieving the encapsulation of pharmaceutical compounds through a self-assembly process to form nanoconstructs that control the biodistribution of the active compounds, and therefore minimize systemic side effects. Micelles are formed from amphiphilic polymers in a selective solvent. In biological applications, micelles are formed in water, and their cores are loaded with hydrophobic pharmaceutics, where they are solubilized and are usually delivered through the blood compartment. Even though a large number of polymeric materials that form nanocarrier delivery systems has been investigated, a surprisingly small subset of these technologies has demonstrated potentially curative preclinical results, and fewer have progressed towards commercialization. One of the most promising classes of polymeric materials for drug delivery applications is polypeptides, which combine the properties of the conventional polymers with the 3D structure of natural proteins, i.e., α-helices and β-sheets. In this article, the synthetic pathways followed to develop well-defined polymeric micelles based on polypeptides prepared through ring-opening polymerization (ROP) of N-carboxy anhydrides are reviewed. Among these works, we focus on studies performed on micellar delivery systems to treat cancer. The review is limited to systems presented from 2000-2017.

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“…However, the potential biohazards of engineered inorganic nanoparticles, including their impact on health and environment, have extensively limited their clinical applications. Therefore, researchers have shifted their focus from inorganic to organic nanomaterials, such as poly(lactic-co-glycolic acid), 10,11 chitosan, 12 polypeptides, 13 liposomes, 14 silk fibroin, 15 lipids, [16][17][18] and carbon-based nanomaterials. 19,20 Recently, carbon nanomaterials including carbon nanotubes, 21 carbon nanohorns (CNHs), 22 carbon nanodiamonds, 23 and graphene (GN) 24 have been studied for applications in drug delivery, owing to their excellent biocompatibility, superhydrophilicity, cell internalization property, enhanced permeability and retention (EPR) effect, and flexibility toward surface modifications.…”

Section: Introductionmentioning

confidence: 99%

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

Zhang¹,

Yao²,

Wei³

et al. 2017

IJN

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Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment. The HCSs also displayed excellent immunocompatibility and could rapidly distribute themselves in the cytoplasm to escape lysosomal clearance. More importantly, the HCSs could efficiently deliver doxorubicin (a representative chemotherapeutic drug) to tumor sites, which resulted in significant inhibition of tumor growth in an esophageal xenograft cancer model. This also prolonged the circulation time and altered the biodistribution of the drug. In conclusion, this study revealed a novel drug delivery system for targeted tumor therapy.

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Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors

Cited by 113 publications

References 46 publications

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Micelles Formed by Polypeptide Containing Polymers Synthesized Via N-Carboxy Anhydrides and Their Application for Cancer Treatment

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

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