Engineering of hybrid anticancer drug-loaded polymeric nanoparticles delivery system for the treatment and care of lung cancer therapy

Abstract

Chemotherapy with combination drugs has become one of the most commonly used cancer prevention treatments, with positive clinical results. The goal of this study was to develop compostable polymeric nanomaterials (NMs) for the delivery of puerarin (PRN) and 5-fluorouracil (5FU), as well as to investigate the anticancer activity of the drug delivery system (PRN-5FU NMs) against in vitro and in vivo lung cancer cells. Since double antitumor drugs PRN and 5FU are insufficiently compressed in polymer-based bio-degradable nanoparticles, encapsulation of PRN and 5FU antitumor drugs were coencapsulated with polyethylene glycol and polylactidecoglycolide nanoparticles (NMs) is efficient. The arrangement of PRN NMs, 5FU NMs, and PRN-5FU NMs, as well as the nanoparticles shape and scale, were studied using transmission electron microscopy (TEM). 5FU-PRN NMs triggered apoptosis in lung carcinoma cell lines such as HEL-299 and A549 in vitro. Acridine orange/ethidium bromide (AO/EB) and nuclear damaging staining techniques were used to observe morphologies and cell death. The mechanistic analysis of apoptosis was also confirmed by flow cytometry analysis using dual staining. When compared to free anticancer products, the hemolysis analysis findings of the 5FU-PRN NMs showed excellent biocompatibility. Taken together the advantages, this combination drug conveyance strategy exposed that 5FU-PRN NMs could have a significant promising to improve the effectiveness of lung cancer cells.

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

“…Given their excellent applicability, polymeric nanoparticles are the most extensively studied drug delivery carriers to date, not only for local anesthetics, 11 but also anticancer agents. 86 , 87 Wang et al recently presented a comprehensive review on polymer-based delivery platforms for local anesthetics, which addressed their advantages and key future challenges. 11 In the current review, we have focused on the different types of polymer-based nanoparticles and the relevant data obtained in this context.…”

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

“…Functional “inner and outer” drug fiber membranes can also be used to regenerate tissue [ 179 ]. Additionally, the dioleyl phosphatidic acid (DOPA) carrier wrapped puerarin 5-FU formed biodegradable polymer nanoparticles, and novel puerarin nanoemulsion (nanoPue), pegylated nanoparticles, GO-based nanoplatform, and vesicular encapsulation technology-based GB-PUE-ribosome complex intravenous injection preparations can also improve the efficacy of puerarin [ 180 , 181 , 182 , 183 , 184 ].…”