Engineering of the carotenoid pathway in Xanthophyllomyces dendrorhous leading to the synthesis of zeaxanthin

Pollmann, Hendrik; Breitenbach, Jürgen; Sandmann, Gerhard

doi:10.1007/s00253-016-7769-0

Cited by 33 publications

(16 citation statements)

References 31 publications

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“…The amenability of fungi to genetic manipulation and industrial cultivation makes some of them ideal choices for biotechnological carotenoid production, as that of -carotene or lycopene by B. trispora, or astaxanthin by X. dendrorhous [168]. The availability of genetic engineering tools for X. dendrorhous has allowed its use for the production of alternative xanthophylls such as zeaxanthin [169] or new ketocarotenoids [170].…”

Section: Fungimentioning

confidence: 99%

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

Rodríguez‐Concepción

Ávalos

Bonet

et al. 2018

Progress in Lipid Research

754

584

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Carotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic organisms and some non-photosynthetic prokaryotes and fungi. With some notable exceptions, animals (including humans) do not produce carotenoids de novo but take them in their diets. In photosynthetic systems carotenoids are essential for photoprotection against excess light and contribute to light harvesting, but perhaps they are best known for their properties as natural pigments in the yellow to red range. Carotenoids can be associated to fatty acids, sugars, proteins, or other compounds that can change their physical and chemical properties and influence their biological roles. Furthermore, oxidative cleavage of carotenoids produces smaller molecules such as apocarotenoids, some of which are important pigments and volatile (aroma) compounds. Enzymatic breakage of carotenoids can also produce biologically active molecules in both plants (hormones, retrograde signals) and animals (retinoids). Both carotenoids and their enzymatic cleavage products are associated with other processes positively impacting human health. Carotenoids are widely used in the industry as food ingredients, feed additives, and supplements. This review, contributed by scientists of complementary disciplines related to carotenoid research, covers recent advances and provides a perspective on future directions on the subjects of carotenoid metabolism, biotechnology, and nutritional and health benefits.

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Section: Fungimentioning

confidence: 99%

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

Rodríguez‐Concepción

Ávalos

Bonet

et al. 2018

Progress in Lipid Research

754

584

View full text Add to dashboard Cite

show abstract

“…[25] who, under limited conditions, used ketogenic-diets on certain cancer sufferers, warned, "People are doing whatever they can to lose weight and keep off. Any of them took the ketogenic diet a notch higher, to use a feeding tube implanted via the nasal into the stomach [23].…”

Section: Findings and Discussionmentioning

confidence: 99%

“…• Gluconeogenesis: the system transforms fat as well as proteins into food carbohydrates. The cycle will consume a lot of extra calories every day [23].…”

Section: The Mechanism Of Ketogenic-diet In Reducing the Weight Of Oumentioning

confidence: 99%

The Effect of Ketogenic-Diet on Health

Alharbi¹,

Al-Sowayan²

2020

FNS

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In recent years, the ketogenic diet is the most popular diet around the world. Therefore, keto diet, short for ketogenic, involves eating a high amount of fat, a moderate amount of protein and very few carbs. This research paper aims to know about the effect of a ketogenic diet on our body, to know about the mechanism of the ketogenic diet in treating neurodegenerative disorders and to know about the mechanism of the ketogenic diet in reducing the weight of our body. Also, the objective was to investigate the ketogenic diet stimulates ketogenesis which treats certain neurodegenerative disorders. Although this is high fats containing food it is beneficial for our body in certain conditions. It is also useful in the conditions in which the brain requires a low level of glucose so the brain starts utilizing ketone bodies. As the intake of carbohydrates is lowered so it is also used to reduce the weight of the body. In this research, the qualitative methodology has been adopted which refers to secondary sources of data. In this project, I used a variety of research that has also been undertaken by numerous researchers including dietitians who tend to support the positive benefits of using ketogenic diets to manage losing weight as well as other health problems that could result from overweight. Also, we used a table to show the difference between studies. Finally, it is important to note that the ketogenic-diet has created debate, partially although traditional dietary education has, for years, illustrated the adverse effects of high overall including trans-fat intake.

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“…Although both lutein and zeaxanthin are used as colorants and potentially in pharmaceutical and nutraceutical industries, the demand for alternative sources of zeaxanthin is more urgent than lutein. Till now, X. dendrorhous has been engineered to produce 10 mg/L of zeaxanthin [80]. The first attempt to produce zeaxanthin in E. coli achieved 11.9 mg/ g DCW in bioreactors [81].…”

Section: Progress In Carotenoid Researchmentioning

confidence: 99%

Biosynthesis of Carotenoids and Apocarotenoids by Microorganisms and Their Industrial Potential

Zhang¹

2018

Progress in Carotenoid Research

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Carotenoids are a large group of natural pigments, ranging from red, to orange, to yellow colors. Synthesized by plants and some microorganisms (e.g., microalgae, fungi and bacteria), carotenoids have important physiological functions (e.g., light harvesting). Apocarotenoids are carotenoid-derived compounds and play important roles in various biological activities (e.g., plant hormones). Many carotenoids and apocarotenoids have high economic value in feed, food, supplements, cosmetics and pharmaceutical industries. Despite high commercial values, they are severely undersupplied because of low abundance in natural hosts (usually a few milligrams per kilogram of raw materials). Furthermore, plants or microbes usually produce mixtures of these molecules with very similar physical and chemical properties (such as α-and β-carotenes). All these features render the extraction from natural hosts rather difficult and also very costly both from process economics and sustainable land-use viewpoints. Chemical synthesis is also expensive due to structural complexity (e.g., astaxanthin has many unsaturated bonds and two chiral regions). Biotechnology via the rapidly advancing metabolic engineering and synthetic biology approaches has led to alternative ways to attain several carotenoids and apocarotenoids at relatively high titers and yields using fast-growing microorganisms. This chapter briefly reviews the biosynthesis of carotenoids and apocarotenoids by microorganisms and their industrial potential.

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Engineering of the carotenoid pathway in Xanthophyllomyces dendrorhous leading to the synthesis of zeaxanthin

Cited by 33 publications

References 31 publications

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

The Effect of Ketogenic-Diet on Health

Biosynthesis of Carotenoids and Apocarotenoids by Microorganisms and Their Industrial Potential

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